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Titolo:
Mechanics of the mammalian cochlea
Autore:
Robles, L; Ruggero, MA;
Indirizzi:
Northwestern Univ, Dept Commun Sci & Disorders, Hugh Knowles Ctr, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 owles Ctr, Evanston, IL 60208 USA Northwestern Univ, Inst Neurosci, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Neurosci, Evanston, IL 60208 USA Univ Chile, Fac Med, Inst Ciencias Biomed, Programa Disciplinario Fisiol &Biofis, Santiago 7, Chile Univ Chile Santiago Chile 7 ciplinario Fisiol &Biofis, Santiago 7, Chile
Titolo Testata:
PHYSIOLOGICAL REVIEWS
fascicolo: 3, volume: 81, anno: 2001,
pagine: 1305 - 1352
SICI:
0031-9333(200107)81:3<1305:MOTMC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG COCHLEA; OUTER HAIR-CELLS; AUDITORY-NERVE FIBERS; BASILAR-MEMBRANE MOTION; LOW-FREQUENCY TONES; SPONTANEOUS OTOACOUSTIC EMISSIONS; TEMPORAL-BONE PREPARATION; OLIVOCOCHLEAR BUNDLE STIMULATION; 2-TONE RATE SUPPRESSION; LOW-SIDE SUPPRESSORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
425
Recensione:
Indirizzi per estratti:
Indirizzo: Ruggero, MA Northwestern Univ, Dept Commun Sci & Disorders, Hugh Knowles Ctr, 2299 N Campus Dr, Evanston, IL 60208 USA Northwestern Univ 2299 N Campus Dr Evanston IL USA 60208 8 USA
Citazione:
L. Robles e M.A. Ruggero, "Mechanics of the mammalian cochlea", PHYSIOL REV, 81(3), 2001, pp. 1305-1352

Abstract

In mammals, environmental sounds stimulate the auditory receptor, the cochlea, via vibrations of the stapes, the innermost of the middle ear ossicles. These vibrations produce displacement waves that travel on the elongated and spirally wound basilar membrane (BM). As they travel, waves grow in amplitude, reaching a maximum and then dying out. The location of maximum BM motion is a function of stimulus frequency, with high-frequency waves being localized to the "base" of the cochlea (near the stapes) and low-frequency waves approaching the "apex" of the cochlea. Thus each cochlear site has a characteristic frequency (CF), to which it responds maximally. BM vibrations produce motion of hair cell stereocilia, which gates stereociliar transduction channels leading to the generation of hair cell receptor potentials and the excitation of afferent auditory nerve fibers. At the base of the cochlea, BM motion exhibits a CF-specific and level-dependent compressive nonlinearity such that responses to low-level, near-CF stimuli are sensitive and sharply frequency-tuned and responses to intense stimuli are insensitive and poorly tuned. The high sensitivity and sharp-frequency tuning, as well as compression and other nonlinearities (two-tone suppression and intermodulation distortion), are highly labile, indicating the presence in normal cochleae of a positive feedback from the organ of Corti, the "cochlear amplifier. " This mechanism involves forces generated by the outer hair cells and controlled, directly or indirectly, by their transduction currents. At the apex of the cochlea, nonlinearities appear to be less prominent than at thebase, perhaps implying that the cochlear amplifier plays a lesser role in determining apical mechanical responses to sound. Whether at the base or the apex, the properties of BM vibration adequately account for most frequency-specific properties of the responses to sound of auditory nerve fibers.

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Documento generato il 01/12/20 alle ore 01:17:31