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Titolo:
Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II - Tissue distribution
Autore:
Bargoni, A; Cavalli, R; Zara, GP; Fundaro, A; Caputo, O; Gasco, MR;
Indirizzi:
Univ Turin, Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy Univ Turin Turin Italy I-10125 ci & Tecnol Farmaco, I-10125 Turin, Italy Univ Turin, Dipartimento Fisiopatol Clin, I-10125 Turin, Italy Univ TurinTurin Italy I-10125 nto Fisiopatol Clin, I-10125 Turin, Italy Univ Turin, Dipartimento Anat Farmacol & Med Legale, I-10125 Turin, Italy Univ Turin Turin Italy I-10125 rmacol & Med Legale, I-10125 Turin, Italy
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 5, volume: 43, anno: 2001,
pagine: 497 - 502
SICI:
1043-6618(200105)43:5<497:TTOTII>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOSOME-ENCAPSULATED TOBRAMYCIN; PSEUDOMONAS-AERUGINOSA; P-GLYCOPROTEIN; INHALED TOBRAMYCIN; CYSTIC-FIBROSIS; NON-STEALTH; BRAIN; DELIVERY; BIOAVAILABILITY; ANTIBIOTICS;
Keywords:
duodenal administration; intravenous administration; tobramycin-loaded solid lipid nanoparticles; tobramycin tissue distribution; blood-brain barrier;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Gasco, MR Univ Turin, Dipartimento Sci & Tecnol Farmaco, Via P Giuria 9, I-10125 Turin, Italy Univ Turin Via P Giuria 9 Turin Italy I-10125 0125 Turin, Italy
Citazione:
A. Bargoni et al., "Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II - Tissue distribution", PHARMAC RES, 43(5), 2001, pp. 497-502

Abstract

Tobramycin-loaded solid lipid nanoparticles (SLN) were prepared and administered by duodenal and intravenous (i.v.) routes to rats and the tissue distributions were determined successively at fixed times (30 min, 4 h and 24 h) and compared to those of the tobramycin solution after i.v. administration. The tissue distribution between tobramycin-loaded SLN administered duodenally and i.v. was different.. A marked difference between tobramycin-loaded SLN administered duodenally and tobramycin solution administered i.v. was also evidenced. In particular, the amounts of tobramycin in the kidneys after tobramycin-loaded SLN administration either duodenally or i.v. were lowerthan after administration of i.v. solution. Tobramycin-loaded SLN were able to pass across the blood-brain barrier in rats to a greater extent after i.v. injection than after duodenal administration. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 13:32:05