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Titolo:
Rebamipide prevents periarterial blood-induced vasospasm in the rat femoral artery model
Autore:
Choi, JM; Shin, YW; Hong, KW;
Indirizzi:
Pusan Natl Univ, Coll Med, Dept Pharmacol, Seo Gu, Pusan 602739, South Korea Pusan Natl Univ Pusan South Korea 602739 o Gu, Pusan 602739, South Korea
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 5, volume: 43, anno: 2001,
pagine: 489 - 495
SICI:
1043-6618(200105)43:5<489:RPPBVI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; SUBARACHNOID HEMORRHAGE; CEREBRAL VASOSPASM; ACTIVATED NEUTROPHILS; SUPEROXIDE-DISMUTASE; CELL-DAMAGE; OXYHEMOGLOBIN; PATHOGENESIS; HEMOGLOBIN; MACROPHAGES;
Keywords:
periarterial blood; superoxide; ICAM-1; rebamipide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hong, KW Pusan Natl Univ, Coll Med, Dept Pharmacol, Seo Gu, Ami Dong 1 Ga,Pusan 602739, South Korea Pusan Natl Univ Ami Dong 1 Ga Pusan South Korea602739 uth Korea
Citazione:
J.M. Choi et al., "Rebamipide prevents periarterial blood-induced vasospasm in the rat femoral artery model", PHARMAC RES, 43(5), 2001, pp. 489-495

Abstract

We examined the effect of rebamipide on the vasospasm induced by periarterial blood. In the in vitro study, the significant production of superoxide anion that was identified 3 hours after application of 10% whole blood to the rat aortic segments was inhibited by rebamipide (100 and 300 muM) and these results were correlated with the in vitro intercellular adhesion molecule-1 (ICAM-1) expression on the femoral artery. In the in vivo study, therewas an increased mobilization of granulocytes in parallel with a large expression of ICAM-1 in the vessels 24 hours after periarterial blood was applied to the femoral artery which then declined. Subsequently, infiltration of macrophages progressively increased at all layers 7-12 days after application. Pretreatment with rebamipide (100 and 300 mg kg(-)1 day(-1), p.o.) significantly inhibited the morphological changes as well as the expression of ICAM-1 with inhibition of granulocyte/macrophage mobilization. In association with these findings, increased wall thickness and decreased lumen areawere significantly inhibited by pretreatment with rebamipide. These results provide valuable information for the therapeutic use of rebamipide to relieve vascular remodeling induced by periarterial blood. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 18:14:17