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Titolo:
Changes of [H-3]MK-801, [H-3]muscimol and [3H]flunitrazepam binding in ratbrain by the prolonged ventricular infusion of ginsenoside Rc and Rg1
Autore:
Kim, HS; Hwang, SL; Nah, SY; Oh, S;
Indirizzi:
Ewha Womans Univ, Coll Med, Dept Neurosci, Seoul 158710, South Korea Ewha Womans Univ Seoul South Korea 158710 sci, Seoul 158710, South Korea Chungbuk Natl Univ, Coll Pharm, Dept Pharmacol, Cheongju 361763, South Korea Chungbuk Natl Univ Cheongju South Korea 361763 ongju 361763, South Korea Chonnam Natl Univ, Coll Vet Med, Dept Physiol, Kwangju 500757, South KoreaChonnam Natl Univ Kwangju South Korea 500757 Kwangju 500757, South Korea
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 5, volume: 43, anno: 2001,
pagine: 473 - 479
SICI:
1043-6618(200105)43:5<473:CO[[A[>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR; NMDA RECEPTORS; PANAX-GINSENG; HIPPOCAMPUS; SUBUNIT; GABA(A); COMPLEX; CALCIUM; LIGAND; CELLS;
Keywords:
ginsenoside; autoradiography; NMDA receptor; GABA(A) receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Oh, S Ewha Womans Univ, Coll Med, Dept Neurosci, Seoul 158710, South KoreaEwha Womans Univ Seoul South Korea 158710 eoul 158710, South Korea
Citazione:
H.S. Kim et al., "Changes of [H-3]MK-801, [H-3]muscimol and [3H]flunitrazepam binding in ratbrain by the prolonged ventricular infusion of ginsenoside Rc and Rg1", PHARMAC RES, 43(5), 2001, pp. 473-479

Abstract

In the present study, we have investigated the effects of centrally administered ginsenoside Re and Rg1 on the modulation of the NMDA receptor and GABAA receptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [H-3]MK-801 binding, and the GABA(A) receptor bindings were analysed by using [H-3]muscimol and [H-3]flunitrazepam binding in rat brain slices. Rats were infused with ginsenoside Re or Rg1(10 mug/10 mu lh(-1), i,c.v.) for 7 days, through pre-implanted cannula using osmotic minipumps (Alzet, model 2ML). The levels of [H-3] MK-801 binding were highly decreased in part of the parietal layers of the cortex and cingulated by ginsenoside Rc and Rg1. The levels of [H-3]muscimol binding were strongly elevated in almost all regions of the frontal cortex by the treatment of ginsenoside Re but decreased by ginsenoside Rg1. However, the [H-3]flunitrazepam binding was not modulated by ginsenoside Rc or Rg1 infusion. These results suggest that prolonged infusion of ginsenosides could differentially modulate [3H]MK-801 and [H-3]muscimol binding in a region-specificmanner. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 15:03:50