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Titolo:
Current perspectives on the development of non-biogenic amine-based antidepressants
Autore:
Skolnick, P; Legutko, B; Li, X; Bymaster, FP;
Indirizzi:
Eli Lilly & Co, Lilly Corp Ctr, Neurosci Discovery, Indianapolis, IN 46285USA Eli Lilly & Co Indianapolis IN USA 46285 overy, Indianapolis, IN 46285USA
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 5, volume: 43, anno: 2001,
pagine: 411 - 422
SICI:
1043-6618(200105)43:5<411:CPOTDO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; SELECTIVE GLUTAMATE RECEPTORS; MESSENGER-RNA LEVELS; NEUROTROPHIC FACTOR; NMDA RECEPTOR; RAT HIPPOCAMPUS; IN-VIVO; AMPA RECEPTORS; EXTRACELLULAR 5-HYDROXYTRYPTAMINE; PREFRONTAL CORTEX;
Keywords:
NMDA antagonists; AMPA receptor potentiators; brain-derived neurotrophic factor; LY392098; biogenic amines; antidepressants;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Skolnick, P DOV Pharmaceut Inc, 433 Hackensack Ave, Hackensack, NJ 07601 USA DOV Pharmaceut Inc 433 Hackensack Ave Hackensack NJ USA 07601
Citazione:
P. Skolnick et al., "Current perspectives on the development of non-biogenic amine-based antidepressants", PHARMAC RES, 43(5), 2001, pp. 411-422

Abstract

Compounds that inhibit the re-uptake and/or metabolism of biogenic amines (i.e. serotonin, norepinephrine, and dopamine) have been used to treat depression for more than CO years, Selective re-uptake inhibitors, currently the most widely prescribed class of biogenic amine-based agents, are certainly safe and relatively easy to use, but do not exhibit either a faster onsetof action or greater efficacy than their predecessors. An approach to overcome the limitations that may be inherent to these 'conventional' therapiesis to circumvent the monoaminegic synapse. In this review, two potential antidepressant strategies are discussed that may converge with intracellularpathways impacted by chronic treatment with biogenic amine-based agents. Drugs emerging from these strategies may offer significant advantages over currently used antidepressants. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:18:50