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Titolo:
Population screening for isoniazid acetylator phenotype
Autore:
Seifart, HI; Parkin, DP; Botha, FJH; Donald, PR; Van der Walt, BJ;
Indirizzi:
Univ Stellenbosch, Sch Med, Dept Pharmacol, ZA-7505 Tygerberg, South Africa Univ Stellenbosch Tygerberg South Africa ZA-7505 Tygerberg, South Africa Univ Stellenbosch, Dept Paediat & Child Hlth, ZA-7505 Tygerberg, South Africa Univ Stellenbosch Tygerberg South Africa ZA-7505 Tygerberg, South Africa
Titolo Testata:
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
fascicolo: 2, volume: 10, anno: 2001,
pagine: 127 - 134
SICI:
1053-8569(200103/04)10:2<127:PSFIAP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-ACETYLATION; GENOTYPE; DRUG; POLYMORPHISM; TUBERCULOSIS; CHILDREN; SLOW; HIV;
Keywords:
isoniazid; arylamine N-acetyltransferase; acetylation; phenotype; polymorphism; trimodality; efficacy; bioavailability; drug monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Van der Walt, BJ Univ Stellenbosch, Sch Med, Dept Pharmacol, POB 19063, ZA-7505 Tygerberg, South Africa Univ Stellenbosch POB 19063 Tygerberg South Africa ZA-7505
Citazione:
H.I. Seifart et al., "Population screening for isoniazid acetylator phenotype", PHARMA D S, 10(2), 2001, pp. 127-134

Abstract

Purpose - To establish a useful method for acetylator phenotypification and therapeutic drug monitoring of patients receiving isoniazid. Methods - Sixty patients with uncomplicated pulmonary tuberculosis were given a 5-mg/kg oral dose of isoniazid each. Plasma concentrations of isoniazid and its metabolite, acetyl-isoniazid, were determined by HPLC analyses at various postdose times. From the isoniazid concentration and the concentration ratio of acetyl-isoniazid and isoniazid (metabolic ratio), phenotypification methods were assessed. Results - The metabolic ratios at 3 h post-dose revealed a trimodal distribution; a fast, intermediate and slow acetylator phenotype group. The 2-h and 6-h data showed different bimodal combinations of these phenotype groups. The metabolic ratio phenotypification method could be simplified by usingthe HPLC data directly without converting it to absolute concentrations. Conclusions - A single-sample test based upon the plasma isoniazid concentration, combined with the metabolic ratio of acetyl-isoniazid and isoniazid, appears to be a reliable parameter for phenotype discrimination and for bioavailability testing. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 08:00:12