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Titolo:
Methylphenidate in children with hyperactivity: review and cost-utility analysis
Autore:
Gilmore, A; Milne, R;
Indirizzi:
London Sch Hyg & Trop Med, ECOHOST, London WC1B 3DP, England London Sch Hyg & Trop Med London England WC1B 3DP ndon WC1B 3DP, England Univ Southampton, Natl Coordinating Ctr Hlth Technol Assessment, Southampton SO16 7PX, Hants, England Univ Southampton Southampton Hants England SO16 7PX 6 7PX, Hants, England
Titolo Testata:
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
fascicolo: 2, volume: 10, anno: 2001,
pagine: 85 - 94
SICI:
1053-8569(200103/04)10:2<85:MICWHR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT DISORDER; PLACEBO-CONTROLLED EVALUATION; TERM STIMULANT TREATMENT; ADHD CHILDREN; ACADEMIC-PERFORMANCE; CONTROLLED TRIAL; FOLLOW-UP; BOYS; MEDICATION; CLASSROOM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Gilmore, A Avon Hlth Author, Dept Publ Hlth, Kings Sq House,Kings Sq, Bristol BS2 8EE, Avon, England Avon Hlth Author Kings Sq House,Kings Sq BristolAvon England BS2 8EE
Citazione:
A. Gilmore e R. Milne, "Methylphenidate in children with hyperactivity: review and cost-utility analysis", PHARMA D S, 10(2), 2001, pp. 85-94

Abstract

Objective To evaluate the effectiveness and cost effectiveness of methylphenidate in the treatment of children with hyperkinetic disorder as defined using ICD-10 criteria. Design Comprehensive literature review and cost utility analysis comparingmethylphenidate treatment with placebo. Costs and effects were estimated from a NHS perspective according to the methodology developed by the previous South and West Development and Evaluation Committee. The number of Quality Adjusted Life Years (QALYs) gained was estimated by using the Index of Health Related Quality of Life to model treatment effects. Results Evidence from good and medium quality randomized controlled trialsshows benefits of methylphenidate over weeks and months respectively. Evidence beyond 6 months is poorer and it is uncertain whether effects of methylphenidate persist into adolescence and adulthood. Methylphenidate is of reasonable cost-effectiveness when considering short- and medium-term benefits with an estimated cost per QALY of pound7 400 to pound9 200 at 1997 prices. Conclusions Short-term treatment of hyperkinetic children with methylphenidate is effective and cost effective. Copyright (C) 2001 John Wiley & Sons,Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:03:46