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Titolo:
Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits
Autore:
Laine, K; Jarvinen, T; Savinainen, J; Laitinen, JT; Pate, DW; Jarvinen, K;
Indirizzi:
Univ Kuopio, Dept Pharmaceut Chem, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 eut Chem, FIN-70211 Kuopio, Finland Univ Kuopio, Dept Physiol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Physiol, FIN-70211 Kuopio, Finland HortaPharm BV, Amsterdam, Netherlands HortaPharm BV Amsterdam Netherlands rtaPharm BV, Amsterdam, Netherlands Univ Kuopio, Dept Pharmaceut, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 armaceut, FIN-70211 Kuopio, Finland
Titolo Testata:
PHARMACEUTICAL RESEARCH
fascicolo: 4, volume: 18, anno: 2001,
pagine: 494 - 499
SICI:
0724-8741(200104)18:4<494:EOTAIA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS CANNABINOID ANANDAMIDE; RAT-BRAIN; SELECTIVE DETECTION; CB1 RECEPTORS; LOCALIZATION; CELLS; ARACHIDONYLETHANOLAMIDE; AUTORADIOGRAPHY; CYCLODEXTRINS; HYPOTENSION;
Keywords:
anandamide (AEA); N-(4-hydroxyphenyl)arachidonyl amide (AM404); (N-vanillyl)-9-oleamide (olvanil); anandamide transport inhibitors; intraocular pressure (IOP); [S-35]guanosine 5 '-(lambda-thio)triphosphate; autoradiography; rabbits;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Laine, K Univ Kuopio, Dept Pharmaceut Chem, FIN-70211 Kuopio, Finland UnivKuopio Kuopio Finland FIN-70211 FIN-70211 Kuopio, Finland
Citazione:
K. Laine et al., "Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits", PHARM RES, 18(4), 2001, pp. 494-499

Abstract

Purpose. To evaluate the effects of topically applied anandamide transportinhibitors, AM404 and olvanil, on the intraocular pressure (IOP) of normotensive rabbits. To determine if the ocular hypotension induced by topical anandamide (AEA) can be potentiated by co-administered AM404. Methods. Test compounds, in either hydroxypropyl-beta -cyclodextrin (HP-beta -CD) or propylene glycol, were administered unilaterally onto rabbit eyes. To determine if AM403 affects the IOP-profile of PLEA, AM404 was administered ocularly 15 minutes before topical AEA. Phenylmethylsulfonyl fluoride(PMSF) (24 mg/kg, s.c.) was given 30 min before AEA to prevent its catabolism. IOPs of the treated and untreated eyes were measured. The cannabinoid agonist activities of AM404 and olvanil were studied by using [S-35]GTP gammaS autoradiography. Results, Topical AM404 (62.5 mug), in HP-beta -CD vehicle, decreased IOP significantly in treated eyes. AM404 (62.5 mug) induced a significant IOP increase without subsequent decrease when given in propylene glycol vehicle. Olvanil (312.5 mug) caused a significant IOP reduction without provoking aninitial hypertensive phase. These compounds did not significantly affect the IOP of untreated eyes. Co-administered AM404 (125 mug in HP-beta -CD) had no significant effect on the IOP profile of AEA. (62.5 pg). Conclusions, Ocular administration of AM404 or olvanil decreased IOP in rabbits, although AM404 can provoke an initial ocular hypertension and did not potentiate the IOP responses induced by exogenous AEA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:03:42