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Titolo:
Monitoring the intragastric distribution of a colloidal drug carrier modelby magnetic resonance imaging460
Autore:
Faas, H; Schwizer, W; Feinle, C; Lengsfeld, H; de Smidt, C; Boesiger, P; Fried, M; Rades, T;
Indirizzi:
Hoffmann La Roche Ag, PRPI, PRNF, CH-4002 Basel, Switzerland Hoffmann La Roche Ag Basel Switzerland CH-4002 H-4002 Basel, Switzerland Univ Zurich, Inst Biomed Engn & Med Informat, Biophys Grp, Zurich, Switzerland Univ Zurich Zurich Switzerland format, Biophys Grp, Zurich, Switzerland ETH Zurich, Zurich, Switzerland ETH Zurich Zurich SwitzerlandETH Zurich, Zurich, Switzerland Univ Zurich Hosp, Dept Gastroenterol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
PHARMACEUTICAL RESEARCH
fascicolo: 4, volume: 18, anno: 2001,
pagine: 460 - 466
SICI:
0724-8741(200104)18:4<460:MTIDOA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL-TRACT; GAMMA-SCINTIGRAPHY; DOSAGE FORMS; GD-DTPA; ABSORPTION; DELIVERY; HUMANS; MEAL;
Keywords:
intragastric drug distribution; colloidal system; liposomes; solid meal; liquid meal; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Rades, T Hoffmann La Roche Ag, PRPI, PRNF, CH-4002 Basel, Switzerland Hoffmann La Roche Ag Basel Switzerland CH-4002 sel, Switzerland
Citazione:
H. Faas et al., "Monitoring the intragastric distribution of a colloidal drug carrier modelby magnetic resonance imaging460", PHARM RES, 18(4), 2001, pp. 460-466

Abstract

Purpose Monitoring the distribution of drugs or drug delivery systems in the human gastrointestinal tract is an important prerequisite for the designof orally administered drugs. We investigated the intragastric distribution of a colloidal drug delivery system (liposomes containing the contrast agent Gd-DOTA) by magnetic resonance imaging. Methods. Following ingestion of a liquid or a solid meal, gastric distribution of liposomes released from a capsule and the fat component of the solid meal were tracked in 7 healthy subjects for 90 min. Liposomes were identified in gastric content by the increased signal intensity provided by the encapsulated Gd-DOTA. Results, With the liquid meal, liposomes initially formed a layer on the surface before distributing in 86 +/- 2% of gastric content (maximum distribution volume) within 42 +/- 6 min. With the solid meal, maximum distribution (7 +/- 1%, reached within 24 +/- 6 min) was confined to a small volume inthe fundus without forming a layer, suggesting that distribution was related to tire accessible liquid compartment Fat distribution was inhomogeneousand: concentrated in the fundus. Conclusions. Intragastric distribution of a colloidal drug carrier model such as Gd-DOTA-filled liposomes, varies between meals of different composition. These differences can be monitored in three dimensions in humans by MRI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:11:33