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Titolo:
Once-a-day oral dosing regimen of cyclosporin A: Combined therapy of cyclosporin A premicroemulsion concentrates and enteric coated solid-state premicroemulsion concentrates
Autore:
Kim, CK; Shin, HJ; Yang, SG; Kim, JH; Oh, YK;
Indirizzi:
Seoul Natl Univ, Coll Pharm, Kwanak Ku, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 k Ku, Seoul 151742, South Korea Chong Kun Dang Pharmaceut Corp, CKD Res Inst, Cheonan Shi 330830, Chungcheongnam, South Korea Chong Kun Dang Pharmaceut Corp Cheonan Shi Chungcheongnam South Korea 330830 Pochon CHA Univ, Coll Med, Kyounggi Do 487800, South Korea Pochon CHA Univ Kyounggi Do South Korea 487800 gi Do 487800, South Korea
Titolo Testata:
PHARMACEUTICAL RESEARCH
fascicolo: 4, volume: 18, anno: 2001,
pagine: 454 - 459
SICI:
0724-8741(200104)18:4<454:OODROC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-TRANSPLANTATION; PHYSICOCHEMICAL CHARACTERIZATION; MICROEMULSION; TOXICITY; PERMEABILITY; FLURBIPROFEN; ABSORPTION; DELIVERY; PEPTIDES; SYSTEM;
Keywords:
cyclosporin A; microemulsion; controlled release; enteric coating; oral absorption; once-a-day dosing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, CK Seoul Natl Univ, Coll Pharm, Kwanak Ku, San 56-1 Shinlim Dong, Seoul 151742, South Korea Seoul Natl Univ San 56-1 Shinlim Dong Seoul South Korea 151742 ea
Citazione:
C.K. Kim et al., "Once-a-day oral dosing regimen of cyclosporin A: Combined therapy of cyclosporin A premicroemulsion concentrates and enteric coated solid-state premicroemulsion concentrates", PHARM RES, 18(4), 2001, pp. 454-459

Abstract

Purpose. To develop once-a-day oral dosing regimen that provides the bloodlevels of cyclosporin A (CsA) in the therapeutic ranges over 24 hours. Methods. CsA. premicroemulsion concentrates (preME) were formulated from phase diagrams. Enteric-coated solid-state premicroemulsion concentrates (sME) were prepared by coating preME with enteric-coating matrials and solidifying them. CsA was measured using high-performance liquid chromatography orradioimmunoassay. Results. PreME consisted of CsA, oil, and mixture of surfactants and a cosurfactant. PreME spontaneously formed microemulsions in aqueous medium and showed oral absorption profiles similar to Sandimmune: Neoral (R) in dogs. Dispersion of sME in aqueous medium also formed microemulsions. Release rates of CsA from sME depended on pH and the type of enteric-coating materialsand highly correlated with the extent of oral absorption. The co-administration of preME and sME (200 Ing CsA) showed the maximum blood level of CsA.not significantly different from that of preME (100 mg CsA) and the concentration of CsA close to the minimum therapeutic level at 24 hours. Conclusions. The combined treatment of preME and sME provided controlled oral absorption of CsA over a 24-hour period. Such once-a-day dosing regimens will lead to increased patient compliance and reduced episodes of organ rejection after transplantation.

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Documento generato il 16/07/20 alle ore 19:32:25