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Titolo:
Effect of intravenous antibiotics on exercise tolerance (3-min step test) in cystic fibrosis
Autore:
Pike, SE; Prasad, SA; Balfour-Lynn, IM;
Indirizzi:
Royal Brompton & Harefield NHS Trust, Dept Physiotherapy, London, England Royal Brompton & Harefield NHS Trust London England py, London, England Royal Brompton & Harefield NHS Trust, Dept Paediat Resp Med, London, England Royal Brompton & Harefield NHS Trust London England ed, London, England Great Ormond St Hosp Children, Dept Physiotherapy, London WC1N 3JH, England Great Ormond St Hosp Children London England WC1N 3JH WC1N 3JH, England Great Ormond St Hosp Children, Dept Resp Med, London WC1N 3JH, England Great Ormond St Hosp Children London England WC1N 3JH WC1N 3JH, England
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 1, volume: 32, anno: 2001,
pagine: 38 - 43
SICI:
8755-6863(200107)32:1<38:EOIAOE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VARIABILITY; CHILDREN;
Keywords:
cystic fibrosis; exercise testing; exercise tolerance; step test; antibiotics; children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Balfour-Lynn, IM Royal Brompton Hosp, Dept Paediat Resp Med, Sydney St, London SW3 6NP, England Royal Brompton Hosp Sydney St London England SW3 6NPand
Citazione:
S.E. Pike et al., "Effect of intravenous antibiotics on exercise tolerance (3-min step test) in cystic fibrosis", PEDIAT PULM, 32(1), 2001, pp. 38-43

Abstract

Most children with cystic fibrosis (CF) feel better and display more energy after a course of intravenous antibiotics (IVABs), but this is not alwaysreflected by a satisfactory improvement in lung function. We assessed the change in exercise tolerance after treat ment with IVABs using the 3-min step test, and compared it with changes in spirometric lung function and arterial oxygen saturation (SaO(2)). Thirty-six children (mean age,13.8 years) were enrolled from two tertiary CF centers during an inpatient stay for IVABs. After 10-14 days of treatment, there was a significant improvement in median FEV1 from 43% to 57% of predicted Values (P < 0.0001), and median FVC from 66% to 73% of predicted values (P < 0.0001), while median SaO(2) significantly increased from 95% to 96.5% (P < 0.05). This was accompanied by a reduction in resting heart rate (median 118 bpm to 109 bpm, P < 0.005) and subjective breathlessness at rest (median Visual analogue score 2.2 to 0.8, P< 0.005). All outcomes of exercise tolerance were improved after IVABs. There was a reduction in maximum heart Fate (median 156 bpm to 150 bpm, P < 0.05) and an increase in minimum SaO(2) (median 93.5% to 94.5%, P = 0.08) measured during the step test. There was also a reduction in subjective breathlessness (median Visual analogue score of 5.5 to 4.2, P < 0.005) and objective breathlessness (median 15-count score of 3 to 2, P < 0.0001) measured immediately after the step test. Exercise testing was a useful outcome measure for monitoring effectivenessof inpatient therapy, and complemented spirometry and SaO(2) monitoring. The simple ward-based 3-min step test was found to be a particularly suitable method for measuring changes in exercise tolerance in children with CF. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:05:05