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Titolo:
Changes in arterial oxygen tension when weaning neonates from inhaled nitric oxide
Autore:
Sokol, GM; Fineberg, NS; Wright, LL; Ehrenkranz, RA;
Indirizzi:
Indiana Univ, Sch Med, Dept Pediat, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Pediat, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA NICHD, Bethesda, MD USA NICHD Bethesda MD USANICHD, Bethesda, MD USA Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ed, Dept Pediat, New Haven, CT 06510 USA
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 1, volume: 32, anno: 2001,
pagine: 14 - 19
SICI:
8755-6863(200107)32:1<14:CIAOTW>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENT PULMONARY-HYPERTENSION; DOSE-RESPONSE; RESPIRATORY-FAILURE; NEWBORN; MULTICENTER; INFANTS; THERAPY;
Keywords:
neonatal hypoxic respiratory failure; pulmonary hypertension; neonatology; nitric oxide; pulmonary circulation; meconium aspiration; pneumonia; sepsis; respiratory distress syndrome; pulmonary hypoplasia; extracorporeal membrane oxygenation; surfactant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Sokol, GM Indiana Univ, Sch Med, Dept Pediat, 699 West Dr,RR-208, Indianapolis, IN 46202 USA Indiana Univ 699 West Dr,RR-208 Indianapolis IN USA 46202 02 USA
Citazione:
G.M. Sokol et al., "Changes in arterial oxygen tension when weaning neonates from inhaled nitric oxide", PEDIAT PULM, 32(1), 2001, pp. 14-19

Abstract

We set out to evaluate changes in arterial oxygen tension (PaO2) when weaning neonates from inhaled nitric oxide (INO). We reviewed the records of 505 prospectively collected INO weaning attempts on 84 neonates with hypoxic respiratory failure. PaO2 values before and 30 min after weaning attempts were recorded. Relationships between change in PaO2 and decreases in INO concentrations were investigated using regression analysis and ANOVA. PaO2 decreased (-18.7 +/- 1.8 torr; P < 0.001) when weaning INO. A stepwise decline in PaO2 was observed weaning INO from 40 ppm. The greatest decline occurred when INO was discontinued (-42.1 +/- 4.1 torr). Forward: stepwise multiple regression using variables with significant relationships to thedecline in PaO2 identified the specific dose reduction (P <0.001), the prewean PaO2 (P < 0.001), and surfactant therapy (P = 0.018) as the variables best describing the change in PaO2 (P = 0.004, r = 0.51). In conclusion, a graded decline in PaO2 occurs when reducing INO. INO should be weaned to less than 1 ppm before discontinuing its use. Prior surfactant treatment appears to enhance the oxygenation reserve when weaning INO. Published 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:05:39