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Titolo:
Effects of dexamethasone on proliferation, chemotaxis, collagen I, and fibronectin-metabolism of human fetal lung fibroblasts
Autore:
Brenner, RE; Felger, D; Winter, C; Christiansen, A; Hofmann, D; Bartmann, P;
Indirizzi:
Univ Ulm, Dept Orthopaed, Div Biochem Joint & Connect Tissue Dis, D-89081 Ulm, Germany Univ Ulm Ulm Germany D-89081 & Connect Tissue Dis, D-89081 Ulm, Germany Univ Bonn, Dept Neonatol, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 Bonn, Dept Neonatol, D-5300 Bonn, Germany Univ Bonn, Dept Child Pathol, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 n, Dept Child Pathol, D-5300 Bonn, Germany
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 1, volume: 32, anno: 2001,
pagine: 1 - 7
SICI:
8755-6863(200107)32:1<1:EODOPC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOPULMONARY DYSPLASIA; RESPIRATORY-DISTRESS; PULMONARY FIBROSIS; PREMATURE-INFANTS; INFLAMMATION; CORTICOSTEROIDS; VENTILATION; INCREASE; RELEASE;
Keywords:
lung fibroblast; dexamethasone; procollagen I; fibronectin; chemotaxis; lung injury; bronchopulmonary dysplasia; neonatology; pulmonary fibrosis; lung growth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Brenner, RE Univ Ulm, Dept Orthopaed, Div Biochem Joint & Connect Tissue Dis, Oberer Eselsberg 45, D-89081 Ulm, Germany Univ Ulm Oberer Eselsberg 45 Ulm Germany D-89081 Ulm, Germany
Citazione:
R.E. Brenner et al., "Effects of dexamethasone on proliferation, chemotaxis, collagen I, and fibronectin-metabolism of human fetal lung fibroblasts", PEDIAT PULM, 32(1), 2001, pp. 1-7

Abstract

Premature infants at risk for bronchopulmonary dysplasia (BPD) are often treated with dexamethasone (Dex), which has been shown to suppress inflammatory processes in the lung. To elucidate a possible direct influence on the fibroproliferative component of the disease, we studied the effects of Dex in therapeutic and supratherapeutic dosages (5-50 nmol/L) on proliferation,chemotaxis, procollagen I, and fibronectin metabolism of human fetal lung fibroblasts in vitro. Proliferation was inhibited by Dex in a dose-dependent manner. Chemotacticactivity in response to conditioned medium of human fetal fibroblasts alsoshowed a dose-dependent inhibition after pretreatment with Dex. The amountof procollagen I C-terminal propeptide and fibronectin per cell in the cell culture supernatant was increased in the presence of Dex. Our results show that Dex does not uniformly suppress the fibroproliferative activity of human fetal lung fibroblasts, which may explain in pari the unsatisfactory long-term effects of Dex treatment in BPD. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:50:21