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Titolo:
Localization and functions of SP-A and SP-D at mucosal surfaces
Autore:
van Rozendaal, BAWM; van Golde, LMG; Haagsman, HP;
Indirizzi:
Univ Utrecht, Fac Vet Med, Dept Biochem Cell Biol & Hist, NL-3508 TD Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TD 3508 TD Utrecht, Netherlands Univ Utrecht, Grad Sch Anim Hlth, NL-3508 TD Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TD 3508 TD Utrecht, Netherlands
Titolo Testata:
PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
fascicolo: 4, volume: 20, anno: 2001,
pagine: 319 - 339
SICI:
1522-7952(200107/08)20:4<319:LAFOSA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ALVEOLAR MACROPHAGES; PROTEIN-A; PULMONARY SURFACTANT; II CELLS; EPITHELIAL-CELLS; IN-VIVO; LYMPHOCYTE-PROLIFERATION; DEVELOPMENTAL EXPRESSION; EUSTACHIAN-TUBE; CLARA CELLS;
Keywords:
collectin; innate immunity; mucosal immunology; SP-A; SP-D; surfactant;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Haagsman, HP Univ Utrecht, Fac Vet Med, Dept Biochem Cell Biol & Hist, POB80-176, NL-3508 TD Utrecht, Netherlands Univ Utrecht POB 80-176 Utrecht Netherlands NL-3508 TD lands
Citazione:
B.A.W.M. van Rozendaal et al., "Localization and functions of SP-A and SP-D at mucosal surfaces", PEDIAT PATH, 20(4), 2001, pp. 319-339

Abstract

Pulmonary surfactant protein A (SP-A) and D (SP-D), members of the collectin family, are implicated in innate host defense of the lung. Collectins consist of a collagen-like domain and a carbohydrate recognition domain. SP-Aand SP-D recognize and interact with glycoconjugates on the surface of microorganisms. They protect the lung by interacting with a wide variety of potential pathogens, including viruses, bacteria, and fungi. This may result in enhanced killing and/or clearance by phagocytes. Although most extensively studied in the lung, both SP-A and SP-D, or proteins closely resembling SP-A and SP-D, are found in a number of other sites in the body and therefore may play a protective role at other sites than the lung. SP-A and SP-D protein and/or mRNA have been detected at various sites of the body: the respiratory tract, the gastrointestinal tract, the middle ear, and in the peritoneal cavity. The presence of SP-A and SP-D at these mucosal surfaces, in close contact with numerous potentially harmful microorganisms, supports a role for these "lung"-collectins in innate mucosal defense. SP-A and SP-D may be important molecules in a threefold innate defense, particularly in the neonatal period between maternally acquired immunity and a fully developed adaptive immune system; the time interval between first exposure to a pathogen and generation of specific antibodies; and states of impaired immune function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:55:56