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Titolo:
Blood pressure regulation and micronutrients
Autore:
Dakshinamurti, K; Dakshinamurti, S;
Indirizzi:
Univ Manitoba, Fac Med, Dept Biochem & Med Genet, Winnipeg, MB R3E 0W3, Canada Univ Manitoba Winnipeg MB Canada R3E 0W3 et, Winnipeg, MB R3E 0W3, Canada Univ Manitoba, Fac Med, Dept Pediat & Child Hlth, Winnipeg, MB R3E 0W3, Canada Univ Manitoba Winnipeg MB Canada R3E 0W3 th, Winnipeg, MB R3E 0W3, Canada
Titolo Testata:
NUTRITION RESEARCH REVIEWS
fascicolo: 1, volume: 14, anno: 2001,
pagine: 3 - 43
SICI:
0954-4224(200106)14:1<3:BPRAM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; VASCULAR SMOOTH-MUSCLE; PLASMA-RENIN ACTIVITY; DEPENDENT DIABETES-MELLITUS; CARDIOVASCULAR RISK-FACTORS; SYMPATHETIC NERVOUS-SYSTEM; INTRACELLULAR CALCIUM-CONCENTRATION; EPICARDIAL CORONARY-ARTERIES; LEAD-INDUCED HYPERTENSION; FREE-RADICAL FORMATION;
Keywords:
hypertension mechanisms; micronutrients; vitamins; ion channels; calcium; pyridoxal phosphate;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
267
Recensione:
Indirizzi per estratti:
Indirizzo: Dakshinamurti, K Univ Manitoba, Fac Med, Dept Biochem & Med Genet, Winnipeg, MB R3E 0W3, Canada Univ Manitoba Winnipeg MB Canada R3E 0W3 R3E 0W3, Canada
Citazione:
K. Dakshinamurti e S. Dakshinamurti, "Blood pressure regulation and micronutrients", NUTR RES R, 14(1), 2001, pp. 3-43

Abstract

This review attempts to delineate the underlying mechanisms leading to thedevelopment of hypertension as well as the function of vitamins and minerals in the regulation of blood pressure. Physiological processes that regulate cardiac output and systemic vascular resistance impact on the control ofblood pressure. Metabolic abnormalities associated with the tetrad of hypertension, dyslipidaemia, glucose intolerance and obesity share insulin resistance, which might be organ or cell specific, as an underlying feature representing different tissue manifestation of a common cellular ionic defect. As Ca is at the centre of ionic regulation of cellular functions, vitaminsinvolved in Ca regulation have a significant role in the control of blood pressure. The endothelium-dependent vasodilator, NO, is susceptible to oxidative damage. Hence, antioxidant vitamins and related factors regulate blood pressure through protection of NO. Robust evidence for the involvement ofvitamin B-6 (pyridoxine), vitamin C, vitamin D and vitamin E in the regulation of blood pressure have been reported. The well-known roles of Na, K, Ca, Mg and Cl have been explored further. The action of various vitamins on blood pressure regulation cannot always be explained on the basis of their conventionally recognised 'vitamin function'. The non-traditional functionsof vitamins and their derivatives can be exploited as an adjunct to available pharmacological modalities in the treatment of hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:33:28