Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection.
Autore:
Grimm, PC; Nickerson, P; Jeffery, J; Savani, RC; Gough, J; McKenna, RM; Stern, E; Rush, DN;
Indirizzi:
Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Pediat, La Jolla, CA 92093 USA Univ Manitoba, Dept Internal Med, Winnipeg, MB, Canada Univ Manitoba Winnipeg MB Canada Dept Internal Med, Winnipeg, MB, Canada Univ Manitoba, Dept Pathol, Winnipeg, MB, Canada Univ Manitoba Winnipeg MB Canada toba, Dept Pathol, Winnipeg, MB, Canada Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Pediat, Philadelphia, PA 19104 USA
Titolo Testata:
NEW ENGLAND JOURNAL OF MEDICINE
fascicolo: 2, volume: 345, anno: 2001,
pagine: 93 - 97
SICI:
0028-4793(20010712)345:2<93:NATIBR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; CHRONIC TRANSPLANT REJECTION; INTERNATIONAL STANDARDIZATION; MYOFIBROBLAST INVOLVEMENT; SUBCLINICAL REJECTION; HISTOLOGIC DIAGNOSIS; INJURY; HYALURONAN; DIFFERENTIATION; VASCULOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Grimm, PC Univ Calif San Diego, Dept Pediat, 9500 Gilman Dr,MC 0831, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr,MC 0831 La Jolla CA USA 92093
Citazione:
P.C. Grimm et al., "Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection.", N ENG J MED, 345(2), 2001, pp. 93-97

Abstract

Background: Tissue remodeling depends on mesenchymal cells (fibroblasts and myofibroblasts) and is a prominent feature of chronic renal-transplant rejection. It is not known whether the mesenchymal cells that participate in remodeling originate locally or from circulating precursor cells. Methods: We obtained biopsy specimens of renal allografts from six male recipients of an allograft from a female donor, four female recipients of an allograft from a male donor, two male recipients of an allograft from a male donor, and two female recipients of an allograft from a female donor. Allthe allografts were undergoing chronic rejection. We used immunohistochemical methods to identify mesenchymal cells with smooth-muscle alpha- actin and in situ hybridization to identify mesenchymal cells with Y-chromosome DNA. Results: No Y-chromosome bodies were identified in the case of the two renal-allograft specimens in which both the donor and the recipient were female. In the case of the two renal-allograft specimens in which both the donorand the recipient were male, approximately 40 percent of mesenchymal cellscontained a Y-chromosome body. In the case of the six specimens in which the donor was female and the recipient was male, a mean (+/-SD) of 34+/-16 percent of mesenchymal cells in the neointima, 38+/-12 percent of such cellsin the adventitia, and 30+/-7 percent of such cells in the interstitium contained the Y-chromosomal marker, indicating that they originated from the recipient rather than the donor. In the case of the four renal-allograft specimens in which the donor was male and the recipient was female, the respective values were 24+/-15 percent, 33+/-9 percent, and 23+/-8 percent, indicating a persistent population of donor mesenchymal cells. Conclusions: The presence of mesenchymal cells of host origin in the vascular and interstitial compartments of renal allografts undergoing chronic rejection provides evidence that a circulating mesenchymal precursor cell hasthe potential to migrate to areas of inflammation. (N Engl J Med 2001;345:93-7. ) Copyright (C) 2001 Massachusetts Medical Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:36:17