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Titolo:
Blood levels of toxic and essential metals in motor neuron disease
Autore:
Pamphlett, R; McQuilty, R; Zarkos, K;
Indirizzi:
Univ Sydney, Dept Pathol, Mol Neurotoxicol Lab, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ol Lab, Sydney, NSW 2006, Australia Royal Prince Alfred Hosp, Dept Biochem, Sydney, NSW, Australia Royal Prince Alfred Hosp Sydney NSW Australia em, Sydney, NSW, Australia Royal Prince Alfred Hosp, Dept Hematol, Sydney, NSW, Australia Royal Prince Alfred Hosp Sydney NSW Australia ol, Sydney, NSW, Australia
Titolo Testata:
NEUROTOXICOLOGY
fascicolo: 3, volume: 22, anno: 2001,
pagine: 401 - 410
SICI:
0161-813X(200106)22:3<401:BLOTAE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; RETROGRADE AXONAL-TRANSPORT; INORGANIC MERCURY; TRACE-ELEMENTS; RISK-FACTORS; ALS PATIENTS; CADMIUM; LEAD; PLASMA; SELENIUM;
Keywords:
amyotrophic lateral sclerosis; motor neuron disease; heavy metal; essential metal; blood;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Pamphlett, R Univ Sydney, Dept Pathol, Mol Neurotoxicol Lab, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 y, NSW 2006, Australia
Citazione:
R. Pamphlett et al., "Blood levels of toxic and essential metals in motor neuron disease", NEUROTOXICO, 22(3), 2001, pp. 401-410

Abstract

Toxic and essential metals have been implicated in the pathogenesis of sporadic motor neuron disease (SMND), but attempts to measure blood levels of these metals have led to contradictory results. We, therefore, measured blood levels of various metals using paired SMND/controls. In 20 subjects withSMND (15 males, five females, mean age 56.8 years) and 20 partner controls(15 females, five males, mean age 55.0 years) cadmium, lead, mercury, copper, zinc and selenium levels were measured in blood, plasma and red cells with inductively coupled plasma mass spectrometry and manganese levels with atomic absorption spectrophotometry. Results were analysed using non-parametric tests. Hypoosmotic red blood cell fragility was estimated in six SMND/control pairs to see if hemolysis could account for increased metal levels. The plasma cadmium level was significantly raised in SMND cases (P = 0.005), but with considerable overlap between SMND and controls. No other metal levels were significantly different, though plasma lead in SMND had a tendency to be higher than controls. No difference in red cell fragility was found between groups. In conclusion, plasma levels of cadmium were raised in this SMND group, but the biological significant of this is uncertain. The measurement of metals in the blood of SMND cases seems unwarranted for routine diagnostic testing. (C) 2001 Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 11:13:20