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Titolo:
Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA
Autore:
Robinet, EA; Geurts, M; Maloteaux, JM; Pauwels, PJ;
Indirizzi:
Ctr Rech Pierre Fabre, Dept Mol & Cellular Biol, F-81106 Castres, France Ctr Rech Pierre Fabre Castres France F-81106 ol, F-81106 Castres, France Univ Catholique Louvain, Lab Pharmacol Expt, B-1200 Brussels, Belgium UnivCatholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 307, anno: 2001,
pagine: 45 - 48
SICI:
0304-3940(20010706)307:1<45:CTWCAD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; AMPHETAMINE; BINDING;
Keywords:
rat brain; regulators of G-protein signalling; immediate early gene; antipsychotics; dopamine D2 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Pauwels, PJ Ctr Rech Pierre Fabre, Dept Mol & Cellular Biol, 17 Ave Jean Moulin, F-81106 Castres, France Ctr Rech Pierre Fabre 17 Ave Jean Moulin Castres France F-81106
Citazione:
E.A. Robinet et al., "Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA", NEUROSCI L, 307(1), 2001, pp. 45-48

Abstract

Quantitative in situ hybridization on rat coronal brain sections with radiolabelled oligonucleotide probes was performed to investigate the effects of antipsychotic drugs on mRNA levels of regulator of G-protein signalling (RGS) 2 and c-fos. This study demonstrated a similar increase of RGS2 mRNA level in the striatum upon both a single and a 21-day treatment with either haloperidol (2 mg/kg) or risperidone (7.5 mg/kg) in contrast to clozapine (20 mg/kg). Otherwise, the acute c-fos mRNA induction in the striatum was abolished by 74 to 89% upon chronic treatment with either haloperidol or risperidone. In conclusion, the induction of RGS2 mRNA in the striatum, in contrast to the immediate early gene c-fos mRNA, is preserved upon chronic treatment with haloperidol and risperidone. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:10:19