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Titolo:
Noradrenergic modulation of human cortex excitability by the presynaptic alpha(2)-antagonist yohimbine
Autore:
Plewnia, C; Bartels, M; Cohen, L; Gerloff, C;
Indirizzi:
Univ Tubingen, Cort Physiol Res Grp, Dept Neurol, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 Neurol, D-72076 Tubingen, Germany Univ Tubingen, Neurophysiol Sect, Dept Psychiat, D-72076 Tubingen, GermanyUniv Tubingen Tubingen Germany D-72076 ychiat, D-72076 Tubingen, Germany NINDS, Human Cort Physiol Sect, Med Neurol Branch, NIH, Bethesda, MD 20892USA NINDS Bethesda MD USA 20892 Med Neurol Branch, NIH, Bethesda, MD 20892USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 307, anno: 2001,
pagine: 41 - 44
SICI:
0304-3940(20010706)307:1<41:NMOHCE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MOTOR CORTEX; BRAIN INJURY; RECOVERY; AMPHETAMINE; PHARMACOTHERAPY; PLASTICITY; INHIBITION; ABLATION; THERAPY; STROKE;
Keywords:
transcranial magnetic stimulation; motor cortex; yohimbine; motor system excitability; norepinephrine; intracortical facilitation; intracortical inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Gerloff, C Univ Tubingen, Cort Physiol Res Grp, Dept Neurol, Hoppe Seyler Str 3, D-72076 Tubingen, Germany Univ Tubingen Hoppe Seyler Str 3 TubingenGermany D-72076 many
Citazione:
C. Plewnia et al., "Noradrenergic modulation of human cortex excitability by the presynaptic alpha(2)-antagonist yohimbine", NEUROSCI L, 307(1), 2001, pp. 41-44

Abstract

The objective of this study was to determine if yohimbine, a central norepinephrine enhancing drug, increases corticomotoneuronal excitability in intact humans. Transcranial magnetic, stimulation was used to assess excitability of the motor system reflected in the parameters motor threshold, recruitment curve, intracortical inhibition and intracortical facilitation beforeand after oral administration of 20 and 40 mg yohimbine. Oral intake of 40but not 20 mg yohimbine increased slope and plateau of the recruitment curve and intracortical facilitation. Motor threshold and intracortical inhibition remained unchanged. The data show that pharmacological enhancement of central norepinephrine in humans is effective to increase the cortico-motoneuronal excitability. Since cortical excitability is closely linked to neuroplasticity, this observation might be of possible relevance for strategiesto enhance rehabilitative processes after cortical lesions by pairing noradrenergic drugs with motor training. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:38:39