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Titolo:
Interactions between cholinergic and GABAergic neurotransmitters in and around the locus coeruleus for the induction and maintenance of rapid eye movement sleep in rats
Autore:
Mallick, BN; Kaur, S; Saxena, RN;
Indirizzi:
Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India Jawaharlal Nehru Univ New Delhi India 110067 ci, New Delhi 110067, India
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 104, anno: 2001,
pagine: 467 - 485
SICI:
0306-4522(2001)104:2<467:IBCAGN>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; LATERODORSAL TEGMENTAL NUCLEUS; ORAL PONTINE TEGMENTUM; CAT BRAIN-STEM; PARADOXICAL SLEEP; RETICULAR-FORMATION; PREOPTIC AREA; REM-SLEEP; DESYNCHRONIZED SLEEP; WAKING CYCLE;
Keywords:
carbachol; microinjection; noradrenergic neurons; picrotoxin; REM sleep duration per episode; REM sleep frequency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Mallick, BN Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India Jawaharlal Nehru Univ New Delhi India 110067 i 110067, India
Citazione:
B.N. Mallick et al., "Interactions between cholinergic and GABAergic neurotransmitters in and around the locus coeruleus for the induction and maintenance of rapid eye movement sleep in rats", NEUROSCIENC, 104(2), 2001, pp. 467-485

Abstract

The noradrenergic "REM-off"neurons in the locus coeruleus cease firing, whereas some cholinegic and non-cholinereic "REM-on" neurons increase firing during rapid eye movement sleep. A reciprocal interaction between these neurons was proposed. However, acetylcholine did not inhibit neurons in the locus coeruleus. Nevertheless, since GABA Levels increase during rapid eye movement sleep and picrotoxin injections into the locus coeruleus reduced rapid eye movement sleep, it was hypothesized that GABA in the locus coeruleusmight play an intermediary inhibitory role for rapid eye movement sleep regulation. Therefore, the effects of GABA or carbachol (a mixed cholinergic agonist receptor) alone, as well as an agonist of one in presence of an antagonist of the other, in the locus coeruleus were investigated on sleep-wakefulness and rapid eye movement sleep. The cholinergic agonist carbachol increased, while the muscarinic antagonist receptor scopolamine decreased, the frequency of induction of rapid eye movement sleep per hour. In contrast, GABA and picrotoxin increased and decreased, respectively, the duration of rapid eye movement sleep per episode. However, when carbachol was injected in the presence of picrotoxin or GABAwas injected in the presence of scopolamine, the effect of GABA or picrotoxin was dominant. Microinjection of both scopolamine and picrotoxin in combination reduced both the frequency of initiation as well as the duration per episode of rapid eye movement sleep. From these results we suggest that in the locus coeruleus cholinergic input modulates the frequency of induction of rapid eye movement sleep and thisaction is mediated through GABA interneurons, whereas the length of rapid eye movement sleep per episode is maintained by the presence of an optimum level of GABA. A model of neural connections for initiation and maintenanceof rapid eye movement sleep is proposed and discussed. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:24:10