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Titolo:
Pedunculopontine stimulation induces prolonged activation of pontine reticular neurons
Autore:
Garcia-Rill, E; Skinner, RD; Miyazato, H; Homma, Y;
Indirizzi:
Univ Arkansas Med Sci, Dept Anat, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 104, anno: 2001,
pagine: 455 - 465
SICI:
0306-4522(2001)104:2<455:PSIPAO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENCEPHALIC LOCOMOTOR REGION; HIGH-FREQUENCY STIMULATION; PLATEAU POTENTIALS; TEGMENTAL NUCLEUS; ACOUSTIC STARTLE; BRAIN-STEM; REM-SLEEP; RAT; CAT; PROJECTIONS;
Keywords:
locomotion; nucleus reticularis pontis caudalis; nucleus reticularis pontis oralis; reticular activating system; sleep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Rill, E Univ Arkansas Med Sci, Dept Anat, 4301 W Markham St, LittleRock, AR 72205USA Univ Arkansas Med Sci 4301 W Markham St Little Rock AR USA 72205
Citazione:
E. Garcia-Rill et al., "Pedunculopontine stimulation induces prolonged activation of pontine reticular neurons", NEUROSCIENC, 104(2), 2001, pp. 455-465

Abstract

Extracellular and intracellular recordings were carried out from neurons in the region of the pontine reticular formation at the transition between the nucleus reticularis pontis oralis and caudalis. and in the pontis caudalis. Responses were studied after stimulation of the mesopontine cholinergicpedunculopontine nucleus in precollicular-postmammillary transected, paralyzed preparations. Recordings of neurographic activity in hindlimb flexor and er;tensor nerves served to detect changes in fictive locomotion and muscle tone induced by pedunculopontine nucleus stimulation or occurring spontaneously. Short duration trains of pedunculopontine nucleus stimulation induced long lasting responses, on average over 12s in duration, in one-third of pontine reticular neurons. These prolonged responses were stimulation frequency-dependent such that the longest durations were induced by stimulation at 20-60 Hz. In some cells, stimulation at lower (10 Hz) or higher (100 Hz) frequencies induced responses of shorter duration or were absent, while in others, higher frequencies prolonged the excitatory effects of pedunculopontine nucleus stimulation. We conclude that these stimulation frequency-dependent effects may be related to the modulation of postural muscle tone and locomotion by the pedunculopontine nucleus. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:38:43