Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bidirectional modulation of basal forebrain N-methyl-D-aspartate receptor function differentially affects visual attention but not visual discrimination performance
Autore:
Turchi, J; Sarter, M;
Indirizzi:
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Psychol, Columbus, OH 43210 USA Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 pt Neurosci, Columbus, OH 43210 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 104, anno: 2001,
pagine: 407 - 417
SICI:
0306-4522(2001)104:2<407:BMOBFN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL ACETYLCHOLINE-RELEASE; BEHAVIORAL VIGILANCE; FLUORO-JADE; ELECTROENCEPHALOGRAM DESYNCHRONIZATION; EXCITOTOXIC LESIONS; COGNITIVE FUNCTIONS; CIS-FLUPENTIXOL; RATS; ACID; AMPHETAMINE;
Keywords:
basal forebrain; glutamate; NMDA; APV; attention; discrimination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Sarter, M Ohio State Univ, Dept Psychol, 27 Townshend Hall, Columbus, OH 43210 USA Ohio State Univ 27 Townshend Hall Columbus OH USA 43210 3210 USA
Citazione:
J. Turchi e M. Sarter, "Bidirectional modulation of basal forebrain N-methyl-D-aspartate receptor function differentially affects visual attention but not visual discrimination performance", NEUROSCIENC, 104(2), 2001, pp. 407-417

Abstract

Basal forebrain neuronal circuits, specifically the corticopetal cholinergic system, mediate attentional abilities. The effects of infusions of N-methyl-D-aspartate (NMDA) and the competitive NMDA receptor antagonist DL-2-amino-5-phosphonovaleric acid (APV) into the basal forebrain were assessed inrats trained in an operant task designed to generate measures of sustainedattention performance. Control animals were trained in a cued visual discrimination task devoid of explicit demands on attentional performance, but involving similar basic operant components as the sustained attention task. The effects of intrabasalis infusions of NMDA (1, 3 and 6 nmol) and APV (3,10 and 70 nmol) were tested in separate groups of animals. Infusion of neither drug affected the animals' response accuracy in the cued visual discrimination task, indicating that performance in this task remains insufficient to activate basal forebrain NMDA receptors. Infusions of APV in sustainedattention task-performing animals selectively decreased the animals' ability to detect visual signals, but spared their ability to reject non-signal events. Conversely, infusions of NMDA into the basal forebrain did not affect the animals' hit rate but increased their number of false alarms, i.e. "claims" for signals in non-signal trials. The concentrations of NMDA infused into the basal forebrain did not result in neurotoxic effects as demonstrated by a separate experiment, which indicated neurodegeneration following the infusion of 30 nmol NMDA as visualized by the Fluoro-Jade method. The effects of APV correspond with the attentional consequences of other manipulations known to impair the functions of cortical cholinergic input. Conversely, the effects of NMDA infusions agree with the hypothesis that overactivity of cortical cholinergic inputs mediates an abnormal overprocessing of the stimulus situation. Basal forebrain NMDA receptor manipulations assist in determining the role of this neuronal system in cognitive processes. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:46:23