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Titolo:
Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment
Autore:
Marksteiner, J; Weiss, U; Weis, C; Laslop, A; Fischer-Colbrie, R; Humpel, C; Feldon, J; Fleischhacker, WW;
Indirizzi:
Innsbruck Univ, Dept Psychiat, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 chiat, A-6020 Innsbruck, Austria Innsbruck Univ, Dept Pharmacol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 macol, A-6020 Innsbruck, Austria Swiss Fed Inst Technol, Dept Behav Neurobiol, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 104, anno: 2001,
pagine: 325 - 333
SICI:
0306-4522(2001)104:2<325:DROCAC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICOTINIC ACETYLCHOLINE-RECEPTOR; MESSENGER-RNA; ADRENAL-MEDULLA; GENE-EXPRESSION; SECRETONEURIN; SCHIZOPHRENIA; IMMUNOREACTIVITY; SYNAPTOPHYSIN; DOPAMINE; PCP;
Keywords:
phencyclidine; gene expression; chromogranin; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Marksteiner, J Innsbruck Univ, Dept Psychiat, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 nnsbruck, Austria
Citazione:
J. Marksteiner et al., "Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment", NEUROSCIENC, 104(2), 2001, pp. 325-333

Abstract

Chromogranin A, chromogranin B and secretogranin II belong to the chromogranin family which consists of large protein molecules that are found in large dense core vesicles. Chromogranins are endoproteolytically processed to smaller peptides. This study was designed to elucidate the regulation of chromgranin expression by acute and subchronic phencyclidine administration. The behavioral syndrome produced by phencyclidine represents a pharmacological model for some aspects of schizophrenia [Jentsch and Roth (1999) Neuropsychopharmacology20, 201-225]. Tissue concentrations of chromogranins were measured with specific radioimmunoassays. Alterations in secretogranin II gene expression were investigated by in situ hybridization. A single dose of phencyclidine (10 mg/kg) led to a transient decrease in secretoneurin tissue levels in theprefrontal cortex after 4 h followed by an increase in secretoneurin tissue levels after 12 h. Repeated phencyclidine treatment (10 mg/kg/day) for five days resulted in elevated secretoneurin levels in cortical areas whereaschromogranin A and chromogranin B tissue levels were unchanged. After the same treatment a significant increase in the number of secretoneurin containing neurons was found in cortical layers II-III, and V-VI as revealed by immunocytochemistry. The increases in secretoneurin levels were paralleled by an increased number of secretogranin II messenger RNA containing neurons as well as by an increased expression of secretogranin II by individual neurons. The present study shows that secretoneurin II tissue concentration and secretogranin II messenger RNA expression is distinctly altered after acute and subchronic phencyclidine application. From these results we suggest that phencyclidine may induce synaptic alterations in specific brain areas and may contribute to a better understanding of synaptic dysfunction which may also occur in schizophrenia. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:14:18