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Titolo:
How do general anaesthetics work?
Autore:
Antkowiak, B;
Indirizzi:
Max Planck Inst Biol Kybernet, D-72076 Tubingen, Germany Max Planck Inst Biol Kybernet Tubingen Germany D-72076 Tubingen, Germany
Titolo Testata:
NATURWISSENSCHAFTEN
fascicolo: 5, volume: 88, anno: 2001,
pagine: 201 - 213
SICI:
0028-1042(200105)88:5<201:HDGAW>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY POSTSYNAPTIC CURRENTS; VOLATILE ANESTHETIC ISOFLURANE; HIPPOCAMPAL PYRAMIDAL NEURONS; CENTRAL-NERVOUS-SYSTEM; GATED ION CHANNELS; GABA(A) RECEPTOR; RAT HIPPOCAMPAL; NEOCORTICAL NEURONS; A RECEPTOR; SYNAPTIC TRANSMISSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Antkowiak, B Max Planck Inst Biol Kybernet, Spermannstr 38, D-72076 Tubingen, Germany Max Planck Inst Biol Kybernet Spermannstr 38 Tubingen Germany D-72076
Citazione:
B. Antkowiak, "How do general anaesthetics work?", NATURWISSEN, 88(5), 2001, pp. 201-213

Abstract

Almost a century ago, Meyer and Overton discovered a linear relationship between the potency of anaesthetic agents to induce general anaesthesia and their ability to accumulate in olive oil. Similar correlations between anaesthetic potency and lipid solubility were later reported from investigations on various experimental model systems. However, exceptions to the Meyer-Overton correlation exist in all these systems, indicating that lipid solubility is an important, but not the sole determinant of anaesthetic action. In the mammalian central nervous system, most general anaesthetics act at multiple molecular sites. It seems likely that not all of these effects are involved in anaesthesia. GABA(A)- and NMDA-receptor/ion channels have already been identified as relevant targets. However, further mechanisms, such asa blockade of Na+ channels and an activation of K+ channels, also come into play. A comparison of different anaesthetics seems to show that each compound has its own spectrum of molecular actions and thus shows specific, fingerprint-like effects on different levels of neuronal activity. This may explain why there is no known compound that specifically antagonises general anaesthesia. General anaesthesia is a multidimensional phenomenon. Unconsciousness, amnesia, analgesia, lass of sensory processing and the depression of spinal motor reflexes are important components. It was not realised until very recently that different molecular mechanisms might underlie these different components. These findings challenge traditional views, such as theassumption that one anaesthetic can be freely replaced by another.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 05:49:22