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Titolo:
Visualization of changes in presynaptic function during long-term synapticplasticity
Autore:
Zakharenko, SS; Zablow, L; Siegelbaum, SA;
Indirizzi:
Columbia Univ, Howard Hughes Med Inst, Ctr Neurobiol & Behav, New York, NY10032 USA Columbia Univ New York NY USA 10032 robiol & Behav, New York, NY10032 USA Columbia Univ, Howard Hughes Med Inst, Dept Pharmacol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ept Pharmacol, New York, NY 10032 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 7, volume: 4, anno: 2001,
pagine: 711 - 717
SICI:
1097-6256(200107)4:7<711:VOCIPF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDIVIDUAL HIPPOCAMPAL SYNAPSES; RAT HIPPOCAMPUS; NERVE-TERMINALS; AMPA RECEPTORS; AREA CA1; POTENTIATION; LTP; TRANSMISSION; BOUTONS; DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Siegelbaum, SA Columbia Univ, Howard Hughes Med Inst, Ctr Neurobiol & Behav, 722 W 168th St, New York, NY 10032 USA Columbia Univ 722 W 168th St New York NY USA 10032 0032 USA
Citazione:
S.S. Zakharenko et al., "Visualization of changes in presynaptic function during long-term synapticplasticity", NAT NEUROSC, 4(7), 2001, pp. 711-717

Abstract

Controversy exists regarding the site of modification of synaptic transmission during long-term plasticity in the mammalian hippocampus. Here we useda fluorescent marker of presynaptic activity, FM 1-43, to directly image changes in presynaptic function during both short-term and long-term forms of plasticity at presynaptic boutons of CA3-CA1 excitatory synapses in acutehippocampal slices. We demonstrated enhanced presynaptic function during long-term potentiation (LTP) induced either chemically (with tetraethylammonium), or by high-frequency (200-Hz) electrical stimulation. Both of these forms of LTP required activation of L-type voltage-gated calcium channels and NMDA receptors in the postsynaptic CA1 neuron. These results thus impliedthat a long-lasting increase in the efficacy of synaptic transmission is likely to depend, at least in part, on enhanced transmitter release from thepresynaptic neuron.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:40:47