Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Recognition of cisplatin adducts by cellular proteins
Autore:
Kartalou, M; Essigmann, JM;
Indirizzi:
MIT, Div Bioengn & Environm Hlth, Dept Chem, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 ironm Hlth, Dept Chem, Cambridge, MA 02139 USA
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 478, anno: 2001,
pagine: 1 - 21
SICI:
1386-1964(20010701)478:1-2<1:ROCABC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICANCER DRUG CISPLATIN; NUCLEOTIDE EXCISION-REPAIR; DNA MISMATCH REPAIR; HMG-DOMAIN PROTEIN; INTERSTRAND CROSS-LINKS; PIGMENTOSUM GROUP-E; NMR SOLUTION STRUCTURE; OVARIAN-CANCER PATIENTS; UPSTREAM BINDING-FACTOR; DETERMINING FACTOR SRY;
Keywords:
cisplatin; trans-DDP; DNA adducts; HMG box proteins; histone H1; TATA binding protein; Y-box binding protein; photolyase; XPE; XPA; RPA; ERCCI; mismatch reapir; 3-methyladenine DNA glycosylase; T4 endonuclease VII and Ku autoantigen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
159
Recensione:
Indirizzi per estratti:
Indirizzo: Essigmann, JM MIT, Div Bioengn & Environm Hlth, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA MIT 77 Massachusetts Ave Cambridge MA USA 02139 MA 02139 USA
Citazione:
M. Kartalou e J.M. Essigmann, "Recognition of cisplatin adducts by cellular proteins", MUT RES-F M, 478(1-2), 2001, pp. 1-21

Abstract

Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA and forms 1,2-d(ApG), 1,2-d(GpG) and 1,3-d(GpTpG) intrastrand crosslinks, interstrand crosslinks and monofunctional adducts. The presence of these adducts in DNA is through to be responsible for the therapeutic efficacy of cisplatin. The exact signal transduction pathway that leadsto cell cycle arrest and cell death following treatment with the drug is not known but cell death is believed to be mediated by the recognition of the adducts by cellular proteins. Here we describe the structural informationavailable for cisplatin and related platinum adducts, the interactions of the adducts with cellular proteins and the implications of these interactions for cell survival. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:46:02