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Titolo:
Altered expression of phospholipase D1 in spontaneously hypertensive rats
Autore:
Min, DS; Lee, KH; Chang, JS; Ahn, BH; Rhie, DJ; Yoon, SH; Hahn, SJ; Kim, MS; Jo, YH;
Indirizzi:
Catholic Univ Korea, Coll Med, Dept Physiol, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea Catholic Univ Korea, Coll Med, Dept Pharmacol, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea Daejin Univ, Dept Life Sci, Kyeonggi 487800, South Korea Daejin Univ Kyeonggi South Korea 487800 ci, Kyeonggi 487800, South Korea
Titolo Testata:
MOLECULES AND CELLS
fascicolo: 3, volume: 11, anno: 2001,
pagine: 386 - 391
SICI:
1016-8478(20010630)11:3<386:AEOPDI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADP-RIBOSYLATION FACTOR; PROTEIN-KINASE-C; SMOOTH-MUSCLE CELLS; ANGIOTENSIN-II; PHOSPHATIDIC-ACID; HL-60 CELLS; ACTIVATION; BINDING; FAMILY; FIBROBLASTS;
Keywords:
kidney; phospholipase D; SHR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Jo, YH Catholic Univ Korea, Coll Med, Dept Physiol, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 137701, South Korea
Citazione:
D.S. Min et al., "Altered expression of phospholipase D1 in spontaneously hypertensive rats", MOL CELLS, 11(3), 2001, pp. 386-391

Abstract

To clarify the involvement of phospholipase D (PLD) in the mechanism underlying genetically-induced hypertension, we investigated the activity and expression levels of PLD in tissues taken from spontaneously hypertensive rats (SHR), and their normotensive controls, Wistar-Kyoto rats (WKY).The ADP-ribosylation factor 3 (ARF3)-dependent PLD activity and protein levels of PLD1 from SBR increased significantly in the brain and liver but not in the heart and kidney, compared to those of WKY. The activity and expression of PLD were the same between the homogenated whole kidneys of the two strains; however, there were topographical differences in the expression and activity of PLD between the kidneys of the two strains. The activity and expression level of PLD gradually increased from the cortex to the inner medulla of WKY, The enzyme activity, and amount of PLD in the inner stripe of the outer medulla and in the inner medulla, was significantly lower in SHR than in WKY, Taken together, these results suggest that the distinctly,distributed patterns of,D in the kidney may be associated with differential signal transduction pathways that are involved in hypertension in conjunction with an increase of PLD activity in the brain and liver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:31:34