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Titolo:
The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage
Autore:
Rep, M; Proft, M; Remize, F; Tamas, M; Serrano, R; Thevelein, JM; Hohmann, S;
Indirizzi:
Univ Gothenburg, Dept Cell & Mol Biol Microbiol, S-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden S-40530 ol, S-40530 Gothenburg, Sweden Katholieke Univ Leuven, Lab Mol Celbiol, B-3001 Louvain, Belgium Katholieke Univ Leuven Louvain Belgium B-3001 l, B-3001 Louvain, Belgium Univ Politecn Valencia, Inst Biol Mol & Celular Plantas, E-46022 Valencia,Spain Univ Politecn Valencia Valencia Spain E-46022 as, E-46022 Valencia,Spain
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 5, volume: 40, anno: 2001,
pagine: 1067 - 1083
SICI:
0950-382X(200106)40:5<1067:TSCSTF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; SKN7 RESPONSE REGULATOR; STRESS-RESPONSE; FISSION YEAST; SALT TOLERANCE; BUDDING YEAST; SCHIZOSACCHAROMYCES-POMBE; SIGNAL-TRANSDUCTION; ELEMENT STRE; BZIP PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Hohmann, S Univ Gothenburg, Dept Cell & Mol Biol Microbiol, Box 462, s-40530 Gothenburg, Sweden Univ Gothenburg Box 462 Gothenburg Sweden s-40530 burg, Sweden
Citazione:
M. Rep et al., "The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage", MOL MICROB, 40(5), 2001, pp. 1067-1083

Abstract

A major part of the transcriptional response of yeast cells to osmotic shock is controlled by the HOG pathway and several downstream transcription factors. Sko1p is a repressor that mediates HOG pathway-dependent regulation by binding to CRE sites in target promoters. Here, we report five target genes of Hog1p-Sko1p: GRE2, AHP1, SFA1, GLR1 and YML131w. The two CREs in theGRE2 promoter function as activating sequences and, hence, bind (an) activator protein(s). However, the two other yeast CRE-binding proteins, Aca1p and Aca2p, are not involved in regulation of the GRE2 promoter under osmoticstress. In the absence of the co-repressor complex Tup1p-Ssn6p/Cyc8p, which is recruited by Sko1p, stimulation by osmotic stress is still observed. These data indicate that Sko1p is not only required for repression, but alsoinvolved in induction upon osmotic shock. All five Sko1p targets encode oxidoreductases with demonstrated or predicted roles in repair of oxidative damage. Altered basal expression levels of these genes in hog1 Delta and sko1 Delta mutants may explain the oxidative stress phenotypes of these mutants. All five Sko1p target genes are induced by oxidative stress, and induction involves Yap1p. Although Sko1p and Yap1p appear to mediate osmotic and oxidative stress responses independently, Sko1p may affect Yap1p promoter access or activity. The five Sko1p target genes described here are suitable models for studying the interplay between osmotic and oxidative responses atthe molecular and physiological levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:33:23