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Titolo:
Prevention of experimental autoimmune encephalomyelitis by encephalitogenic epitope sequence simplified derivatives
Autore:
Marino, M; Ippolito, A; Ruvo, M; Scarallo, A; Volpe, S; Fassina, G;
Indirizzi:
Osped SG Moscati, Avellino, Italy Osped SG Moscati Avellino ItalyOsped SG Moscati, Avellino, Italy TECNOGEN SCpA, I-81015 Piana Di Monte Verna, CE, Italy TECNOGEN SCpA Piana Di Monte Verna CE Italy I-81015 onte Verna, CE, Italy
Titolo Testata:
MOLECULAR IMMUNOLOGY
fascicolo: 16, volume: 37, anno: 2000,
pagine: 951 - 960
SICI:
0161-5890(200011)37:16<951:POEAEB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; T-CELL-RECEPTOR; CLASS-I MHC; 3-DIMENSIONAL STRUCTURE; PEPTIDE; ANTIGEN; COMPLEXES; BINDING; CLONES; ANTAGONISTS;
Keywords:
multiple sclerosis; prevention; simplified peptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Fassina, G TECNOGEN SCpA, Parco Sci, I-81015 Piana Di Monte Verna, CE, Italy TECNOGEN SCpA Parco Sci Piana Di Monte Verna CE Italy I-81015 y
Citazione:
M. Marino et al., "Prevention of experimental autoimmune encephalomyelitis by encephalitogenic epitope sequence simplified derivatives", MOL IMMUNOL, 37(16), 2000, pp. 951-960

Abstract

The encephalitogenic epitope P81-100 from mouse myelin basic protein was used to generate two simplified derivatives with glycine substitutions in alternating positions which were tested for their biological activity in a murine model of multiple sclerosis, experimental autoimmune encephalomyelitis. While both derivatives were unable to induce in mice the disease at the same parent peptide P81-100 dosage. T cell proliferation assays demonstratedtheir ability to compete with the parental peptide in a dose related manner. Experiments of cell surface binding and T cell tolerance revealed a different behavior of the two derivatives, suggesting different roles in the MHC blockade or T cell tolerance. On induction of encephalomyelitis in animals by P81-100 treatment, one variant proved in vivo to be very effective in protecting from the disease. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:55:59