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Titolo:
Stationary-phase mutations in proofreading exonuclease-deficient strains of the yeast Saccharomyces cerevisiae
Autore:
Babudri, N; Pavlov, YI; Matmati, N; Ludovisi, C; Achilli, A;
Indirizzi:
St Petersburg Univ, Dept Genet, St Petersburg 199034, Russia St PetersburgUniv St Petersburg Russia 199034 Petersburg 199034, Russia
Titolo Testata:
MOLECULAR GENETICS AND GENOMICS
fascicolo: 2, volume: 265, anno: 2001,
pagine: 362 - 366
SICI:
1617-4615(200104)265:2<362:SMIPES>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-REPLICATION ERRORS; ADAPTIVE MUTATION; POLYMERASES; DELTA; EPSILON; FAMILY;
Keywords:
Saccharomyces cerevisiae; stationary-phase mutations; pol2-4; pol3-01; exonucleolytic proofreading;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Babudri, N Univ Perugia, Dept Cellular & Mol Biol, Via Pascoli, I-06100 Perugia, Italy Univ Perugia Via Pascoli Perugia Italy I-06100 Perugia, Italy
Citazione:
N. Babudri et al., "Stationary-phase mutations in proofreading exonuclease-deficient strains of the yeast Saccharomyces cerevisiae", MOL GENET G, 265(2), 2001, pp. 362-366

Abstract

In order to understand the role of yeast polymerases in spontaneous mutagenesis in non-growing cells we have studied the effects of mutations that impair the 3 ' --> 5 ' exonuclease function of polymerases delta (pol3-01) and epsilon (pol2-4) on the spontaneous reversion frequency of the frameshiftmutation his7-2 in cells starved for histidine. We showed that for each exonuclease-deficient mutant the rate of reverslon per viable cell per day observed in stationary-phase cells remained constant up to the 9th day of starvation (while the number of viable cells dropped), and was very similar tothat observed in the same mutants during the growth phase. These data suggest that both DNA polymerases are involved in the control of mutability in non-growing cells.

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Documento generato il 13/07/20 alle ore 04:09:21