Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Induction of the SAPK activator MIG-6 by the alkylating agent methyl methanesulfonate
Autore:
van Laar, T; Schouten, T; van der Eb, AJ; Terleth, C;
Indirizzi:
Leiden Univ, Med Ctr, Dept Radiat Genet & Chem Mutagenesis, Med Genet Ctr SW Netherlands, NL-2300 RA Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RA NL-2300 RA Leiden, Netherlands
Titolo Testata:
MOLECULAR CARCINOGENESIS
fascicolo: 2, volume: 31, anno: 2001,
pagine: 63 - 67
SICI:
0899-1987(200106)31:2<63:IOTSAM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION; PROTEIN-KINASES; TYROSINE KINASE; FIBROBLASTS; P38; IMMORTALIZATION; TRANSFORMATION; STRESS; MICE; MMS;
Keywords:
mitogen-inducible gene-6; alkylating agent; c-jun N-terminal kinase/stress-activated protein kinase; differential display;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Terleth, C Leiden Univ, Med Ctr, Dept Radiat Genet & Chem Mutagenesis, MedGenet Ctr SW Netherlands, POB 9503, NL-2300 RA Leiden, Netherlands Leiden Univ POB 9503 Leiden Netherlands NL-2300 RA Netherlands
Citazione:
T. van Laar et al., "Induction of the SAPK activator MIG-6 by the alkylating agent methyl methanesulfonate", MOL CARCINO, 31(2), 2001, pp. 63-67

Abstract

The alkylating agent methylmethanesulfonate (MMS) activates the c-jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and the p38 mitogen-activated protein kinase (p38MAPK) pathways via different mechanisms ofaction. Activation of p38MAPK by MMS involves the pp125 focal adhesion kinase-related tyrosine kinase RAFTK and the MARK kinase 3. The way in which MMS can activate JNK/SAPK has not been elucidated. Here we describe the identification by differential display of human mitogen-activated gene-6 (MIG-6) as a novel MMS-inducible gene. Induction of MIG-6 by MMS was found in human diploid skin fibroblasts and in simian virus 40-transformed skin fibroblasts, indicating that the enhanced expression of MIG-6 after MMS-treatment did not require p53. The signal leading to activation of MIG-6 appeared to be independent of DNA damage. High MIG-6 expression was found in the liver,lung, and placenta. MIG-6 is an adapter protein that binds to the activated form of cdc42Hs and to 14-3-3 proteins, thereby activating JNK/SAPKs. Ourresults suggest that activation of JNK/SAPKs by MMS may involve the induction of MIG-6. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:42:40