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Titolo:
Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes
Autore:
Kneussel, M; Brandstatter, JH; Gasnier, B; Feng, GP; Sanes, JR; Betz, H;
Indirizzi:
Max Planck Inst Brain Res, Dept Neurochem, D-60528 Frankfurt, Germany Max Planck Inst Brain Res Frankfurt Germany D-60528 8 Frankfurt, Germany Max Planck Inst Brain Res, Dept Neuroanat, D-60528 Frankfurt, Germany Max Planck Inst Brain Res Frankfurt Germany D-60528 8 Frankfurt, Germany CNRS, Inst Biol Physicochim, UPR 6 1929, F-75005 Paris, France CNRS Paris France F-75005 Physicochim, UPR 6 1929, F-75005 Paris, France Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 6, volume: 17, anno: 2001,
pagine: 973 - 982
SICI:
1044-7431(200106)17:6<973:GCOPGR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; SUBUNIT MESSENGER-RNAS; RAT SPINAL-CORD; GLYCINE-RECEPTOR; GABAERGIC SYNAPSES; VESICULAR GABA; NEUROTRANSMITTER RECEPTORS; GABA(A)-RECEPTOR SUBTYPES; GLUTAMATERGIC SYNAPSES; HIPPOCAMPAL-NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Betz, H Max Planck Inst Brain Res, Dept Neurochem, Deutschordenstr 46, D-60528 Frankfurt, Germany Max Planck Inst Brain Res Deutschordenstr 46 Frankfurt Germany D-60528
Citazione:
M. Kneussel et al., "Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes", MOL CELL NE, 17(6), 2001, pp. 973-982

Abstract

Gephyrin has been shown to be essential for the synaptic localization of the inhibitory glycine receptor and major GABA(A) receptor (GABA(A)R) subtypes. However, in retina certain GABA(A)R subunits are found at synaptic sites in the absence of gephyrin. Here, we quantitatively analyzed GABA(A)R alpha1, alpha2, alpha3, alpha5, beta2/3, and gamma2 subunit immunoreactivitiesin spinal cord sections derived from wild-type and gephyrin-deficient (geph -/-) mice. The punctate staining of GABA(A)R alpha1 and alpha5 subunits was unaltered in geph -/- mice, whereas the numbers of alpha2-, alpha3-, beta2/3-, and gamma2-subunit-immunoreactive synaptic sites were significantly or even strikingly reduced in the mutant animals. Immunostaining with an antibody specific for the vesicular inhibitory amino acid transporter revealed that the number of inhibitory presynaptic terminals is unaltered upon gephyrin deficiency. These data show that in addition to gephyrin other clustering proteins must exist that mediate the synaptic localization of selectedGABA(A)R subtypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:41:35