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Titolo:
Effect of oleoyl-esterone treatment on the expression of beta(1)- beta(2)-and beta(3)-adrenoreceptors in rat adiopose tissues
Autore:
Cabot, C; del Mar Grasa, M; Fernandez-Lopez, JA; Alemany, M;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Ctr Especial Recerca Nutr & Ciencia Aliments, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 liments, E-08028 Barcelona, Spain
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 221, anno: 2001,
pagine: 109 - 115
SICI:
0300-8177(200105)221:1-2<109:EOOTOT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBCUTANEOUS ADIPOSE-TISSUE; WHITE FAT-CELLS; BETA-3-ADRENERGIC RECEPTOR; ADRENOCEPTOR SUBTYPES; ADRENERGIC-RECEPTORS; MOLECULAR-CLONING; ADENYLYL-CYCLASE; MESSENGER-RNA; ADIPOCYTES; LIPOLYSIS;
Keywords:
beta(1)-adrenoceptors; beta(2)-adrenoceptors; beta(3)-adrenoceptors; oleoyl-estrone; cAMP; white adipose tissue; brown adipose tissue; BAT; WAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Alemany, M Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Ctr EspecialRecerca Nutr & Ciencia Aliments, Av Diagonal 645, E-08028 Barcelona, SpainUniv Barcelona Av Diagonal 645 Barcelona Spain E-08028 , Spain
Citazione:
C. Cabot et al., "Effect of oleoyl-esterone treatment on the expression of beta(1)- beta(2)-and beta(3)-adrenoreceptors in rat adiopose tissues", MOL C BIOCH, 221(1-2), 2001, pp. 109-115

Abstract

Adult female rats received a constant i.v. infusion of oleoyl-estrone (3.5mu mol/kg day) in a lipidic suspension for 14 days. On days 0 (no treatment), 3, 6, 10 and 14, as well as on day 14 for controls (receiving only the lipid); the rats were killed and the expression of the beta (1)-, beta (2)-and beta (3)-adrenoceptor genes, in brown adipose tissue and in subcutaneous and periovaric white adipose tissue, were measured by RNA protection assay, and compared with that of cyclophyllin. The beta (3)-adrenoceptor was the most expressed in all adipose tissues, whereas beta (2) was the less expressed in brown adipose tissue. Oleoyl-estrone significantly, but moderately, increased the expression of beta -adrenoceptors in the three adipose tissues: beta (1) increased in subcutaneous, beta (2) and beta (3) in periovaric and beta (3) in brown adipose tissue. Oleoyl-estrone also decreased beta(3) expression in subcutaneous white adipose tissue. On day 10, adipocytesisolated from periovaric white adipose tissue of oleoyl-estrone-treated rats showed higher cAMP response to an isoproterenol challenge than the controls. The mechanism by which oleoyl-estrone elicits the wasting of fat reserves could be mediated by adrenergic pathways, at least in part.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:13:30