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Titolo:
Hunting genes in Parkinson's disease from the roots
Autore:
Muthane, U; Jain, S; Gururaj, G;
Indirizzi:
Natl Inst Mental Hlth & Neurosci, Dept Neurol, Mol Genet Lab, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci Bangalore Karnataka India 560029 , India Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci Bangalore Karnataka India 560029 , India Natl Inst Mental Hlth & Neurosci, Dept Epidemiol, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci Bangalore Karnataka India 560029 , India
Titolo Testata:
MEDICAL HYPOTHESES
fascicolo: 1, volume: 57, anno: 2001,
pagine: 51 - 55
SICI:
0306-9877(200107)57:1<51:HGIPDF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-NUCLEOTIDE POLYMORPHISMS; MAJOR NEUROLOGICAL DISORDERS; LIPOPROTEIN-LIPASE GENE; CANDIDATE GENES; PREVALENCE; POPULATION; COMMUNITY; INDIA; MICE; FREQUENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Muthane, U Natl Inst Mental Hlth & Neurosci, Dept Neurol, Mol Genet Lab, Hosur Rd, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci Hosur Rd Bangalore Karnataka India 560029
Citazione:
U. Muthane et al., "Hunting genes in Parkinson's disease from the roots", MED HYPOTH, 57(1), 2001, pp. 51-55

Abstract

Parkinson's disease (PD), a common, neurodegenerative disorder, has a worldwide distribution. The genetic basis of PD is not well understood, although some recent leads have emerged. Epidemiological studies suggest that there is significant variation in the prevalence of PD between different populations and rates are highest in populations of European origin. Significant differences in molecular pathology in PD and control brain tissue have beenobserved between African, British and Indian populations. In view of this epidemiological and pathological evidence, it is proposed that allelic variations in genes that predispose to PD may account for the ethnic variation. Advances in our knowledge about the human genome will allow us to make detailed comparisons between affected and control subjects in different populations. This may help us to understand the reasons for the variation, and a better understanding of the genetic processes underlying the disease process. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:07:37