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Titolo:
Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats
Autore:
Goosens, KA; Maren, S;
Indirizzi:
Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Psychol, Ann Arbor, MI 48109 USA Univ Michigan, Program Neurosci, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 am Neurosci, Ann Arbor, MI 48109 USA
Titolo Testata:
LEARNING & MEMORY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 148 - 155
SICI:
1072-0502(200105/06)8:3<148:CAAFCA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL TEMPORAL LOBECTOMY; BASOLATERAL AMYGDALA; POTENTIATED STARTLE; AVOIDANCE-BEHAVIOR; NEUROTOXIC LESIONS; LONG-TERM; PROJECTIONS; NEURONS; ORGANIZATION; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Maren, S Univ Michigan, Dept Psychol, 580 Union Dr, Ann Arbor, MI 48109 USA Univ Michigan 580 Union Dr Ann Arbor MI USA 48109 r, MI 48109 USA
Citazione:
K.A. Goosens e S. Maren, "Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats", LEARN MEM, 8(3), 2001, pp. 148-155

Abstract

A large body of literature implicates the amygdala in Pavlovian fear conditioning. In this study, we examined the contribution of individual amygdaloid nuclei to contextual and auditory fear conditioning in rats. Prior to fear conditioning, rats received a large electrolytic lesion of the amygdala in one hemisphere, and a nucleus-specific neurotoxic lesion in the contralateral hemisphere. Neurotoxic lesions targeted either the lateral nucleus (LA), basolateral and basomedial nuclei (basal nuclei), or central nucleus (CE) of the amygdala. LA and CE lesions attenuated freezing to both contextual and auditory conditional stimuli (CSs). Lesions of the basal nuclei produced deficits in contextual and auditory fear conditioning only when the damage extended into the Interior divisions of the basal nuclei: damage limited to the posterior divisions of the basal nuclei did not significantly impair conditioning to either auditory or contextual CS. These effects were typically not lateralized, although neurotoxic lesions of the posterior divisions of the basal nuclei had greater effects on contextual fear conditioningwhen the contralateral electrolytic lesion was placed in the right hemisphere. These results indicate that there is significant overlap within the amygdala in the neural pathways mediating fear conditioning to contextual andacoustic CS, and that these forms of learning are not anatomically dissociable at the level of amygdaloid nuclei.

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Documento generato il 04/04/20 alle ore 11:35:18