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Titolo:
Fluorescence spectroscopic analysis of circulating platelet activation during coronary angioplasty
Autore:
Christov, A; Kostuk, WJ; Jablonsky, G; Lucas, A;
Indirizzi:
Univ Western Ontario, John P Robarts Res Inst, Vasc Biol Grp, London, ON N6A 5K8, Canada Univ Western Ontario London ON Canada N6A 5K8 London, ON N6A 5K8, Canada London Hlth Sci Ctr, Div Cardiol, London, ON N6A 5B8, Canada London Hlth Sci Ctr London ON Canada N6A 5B8 , London, ON N6A 5B8, Canada Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 5B8, CanadaUniv Western Ontario London ON Canada N6A 5B8 London, ON N6A 5B8, Canada
Titolo Testata:
LASERS IN SURGERY AND MEDICINE
fascicolo: 5, volume: 28, anno: 2001,
pagine: 414 - 426
SICI:
0196-8092(2001)28:5<414:FSAOCP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARIN-INDUCED THROMBOCYTOPENIA; INDUCED CONFORMATIONAL-CHANGES; LOW-DENSITY-LIPOPROTEIN; HUMAN-BLOOD-PLATELETS; MEMBRANE FLUIDITY; NITRIC-OXIDE; INTEGRIN ALPHA(IIB)BETA(3); GLYCOPROTEIN IIB/IIIA; PROCOAGULANT ACTIVITY; ENDOTHELIAL-CELLS;
Keywords:
coronary angioplasty; fluorescence; platelet; membrane fluidity; GP IIb/IIIa receptor antagonist; ADP receptor antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Lucas, A Univ Western Ontario, John P Robarts Res Inst, Vasc Biol Grp, 100Perth Dr,POB 5015, London, ON N6A 5K8, Canada Univ Western Ontario 100 Perth Dr,POB 5015 London ON Canada N6A 5K8
Citazione:
A. Christov et al., "Fluorescence spectroscopic analysis of circulating platelet activation during coronary angioplasty", LASER SURG, 28(5), 2001, pp. 414-426

Abstract

Background and Objective: Platelet activation during percutaneous transluminal coronary angioplasty (PTCA) initiates thrombus formation and plaque regrowth at sites of arterial injury, limiting procedure efficacy. We have developed a simple assay for circulating platelet activation based on fluorescence analysis of membrane fluidity and intracellular calcium concentrationand light scattering analysis of platelet aggregation. Study Design/Materials and Methods: Platelet activation state was measuredin 45 patients undergoing angioplasty, before and after treatment with platelet inhibitors. Results: PTCA alone produced a decrease in pyrene dimer formation (P less than or equal to 0.0083) and an increase in light scattering at 650 nm (P less than or equal to 0.0128). Treatment with ADP and GPIIb/IIIa receptor antagonists reduced PTCA induced changes in pyrene dimer formation. An unexpected decrease in pyrene dimer formation (P less than or equal to 0.05) was detected when the GPIIb/IIIa receptor antagonist was given together with anADP receptor antagonist. Conclusions: 1) Analysis of membrane fluidity provides a sensitive marker for platelet activation state. 2) Reduced membrane fluidity after combined platelet inhibitor treatments suggests reduced antiplatelet efficacy. (C) 2001Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:11:43