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Titolo:
Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin media
Autore:
Wang, F; Dowling, T; Bicker, G; Wyvratt, J;
Indirizzi:
Merck & Co Inc, Merck Res Labs, Dept Analyt Res, Rahway, NJ 07065 USA Merck & Co Inc Rahway NJ USA 07065 Dept Analyt Res, Rahway, NJ 07065 USA
Titolo Testata:
JOURNAL OF SEPARATION SCIENCE
fascicolo: 5, volume: 24, anno: 2001,
pagine: 378 - 384
SICI:
1615-9314(200105)24:5<378:ECSOPC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFATED BETA-CYCLODEXTRIN; CAPILLARY ZONE ELECTROPHORESIS; ENANTIOMERS; SELECTIVITY; ADDITIVES; ENANTIOSEPARATIONS; ELECTROLYTE; BLOCKERS; DRUGS; ACIDS;
Keywords:
capillary electrophoresis; counter-electroosmotic flow setup; single-isomer anionic cyclodextrins; sulfated cyclodextrins; chiral separations; manipulation of migration order;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, F Merck & Co Inc, Merck Res Labs, Dept Analyt Res, POB 2000,RY818-B208, Rahway, NJ 07065 USA Merck & Co Inc POB 2000,RY818-B208 Rahway NJ USA 07065 J 07065 USA
Citazione:
F. Wang et al., "Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin media", J SEP SCI, 24(5), 2001, pp. 378-384

Abstract

This paper reports the use of sulfated beta -cyclodextrins (S-beta -CDs) (degree of substitution (DS) = 7-11 and 15), hepta-6-sulfato-beta -CD (HS-beta -CD), heptakis (2,3-dimethyl-6-sulfato)-beta -CD (HDMS-beta -CD), and heptakis (2,3-diacetyl-6-sulfato)-beta -CD (HDAS-beta -CD) in conjunction with capillary zone electrophoresis (CZE) to separate enantiomers of several commercially available pharmaceutical compounds with multiple stereogenic centers. Compounds studied include eucatropine, fenoterol, nadolol, nafronyl,nylidrin, and pentapiperide. S-beta -CD with a relatively high degree of substitution is shown to be effective in separating several of these compounds due to the high selectivity. Resolution of four isomers was achieved forseveral of the test compounds under counter-electroosmotic flow (EOF) conditions in less than ten minutes. Data illustrating the effects of CD concentration and pH are presented. It is also shown that the migration order of isomers can be manipulated by changing either the CD concentration or buffer pH.

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Documento generato il 29/03/20 alle ore 13:05:45