Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The differential effects of chlorpromazine and haloperidol on latent inhibition in healthy volunteers
Autore:
McCartan, D; Bell, R; Green, JF; Campbell, C; Trimble, K; Pickering, A; King, DJ;
Indirizzi:
Queens Univ Belfast, Dept Therapeut & Pharmacol, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT9 7BL m, North Ireland Queens Univ Belfast, Sch Psychol, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT9 7BL m, North Ireland St Georges Hosp, Sch Med, Dept Psychol, London, England St Georges Hosp London England , Sch Med, Dept Psychol, London, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 96 - 104
SICI:
0269-8811(2001)15:2<96:TDEOCA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIPSYCHOTIC DRUG; EYE-MOVEMENTS; IRRELEVANT STIMULI; COGNITIVE DEFICITS; SCHIZOPHRENIA; MODEL; PEOPLE; PERFORMANCE; ENHANCEMENT; SULPIRIDE;
Keywords:
antipsychotics; cognition; healthy volunteers; latent inhibition; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: King, DJ Queens Univ Belfast, Dept Therapeut & Pharmacol, Whitla Med Bldg,97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Whitla Med Bldg,97 Lisburn Rd Belfast Antrim North Ireland BT9 7BL
Citazione:
D. McCartan et al., "The differential effects of chlorpromazine and haloperidol on latent inhibition in healthy volunteers", J PSYCHOPH, 15(2), 2001, pp. 96-104

Abstract

Latent inhibition (LI) is a measure of reduced learning about a stimulus to which there has; been prior exposure without any consequence. It therefore requires a comparison between a pre-exposed (PE) and a non-pre-exposed (NPE) condition. Since, in animals, LI is disrupted by amphetamines and enhanced by antipsychotics, LI disruption has been proposed as a measure of the characteristic attentional deficit in schizophrenia: the inability to ignore irrelevant stimuli. The findings in humans are, however, inconsistent. Inparticular, a recent investigation suggested that since haloperidol disrupted LI in healthy volunteers, and LI was normal in non-medicated patients with schizophrenia, the previous findings in schizophrenic patients were entirely due to the negative effects of their medication on LI (Williams et al., 1998). We conducted two studies of antipsychotic drug effects on auditory LI using a within-subject, parallel group design in healthy volunteers. In the first of these, single doses of haloperidol (1 mg. i.v.) were compared with paroxetine (20 mg p.o.) and placebo, and in the second, chlorpromazine (100 mg p.o.) was compared with lorazepam (2 mg. p.o.) and placebo. Eye movements, neuropsychological test performance (spatial working memory (SWM), Tower of London and intra/extra dimensional shift, from the CANTAB test battery) and visual analogue rating scales,were also included as other measures of attention and frontal lobe function. Haloperidol was associated with a non-significant reduction in LI scores, and dysphoria/akathisia (BarnesAkathisia Rating Scale) in three-quarters of the subjects. The LI finding may be explained by increased distractibility which was indicated by an increase in antisaccade directional errors in this group. In contrast, LI was significantly increased by chlorpromazine but not by an equally sedative dose of lorazepam (both drugs causing marked decreases in peak saccadic velocity). Paroxetine had no effect on LT, eye movements or CANTAB neuropsychological test performance. Haloperidol was associated with impaired SWM, whichcorrelated with the degree of dysphoria/akathisia, but no other drug effects on CANTAB measures were detected. We conclude that the effect of antipsychotics on LI is both modality and pharmacologically dependent and that further research using a wider range of antipsychotic compounds is necessary to clarify the cognitive effects of these drugs, and to determine whether there are important differences between them.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:29:52