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Titolo:
Serotonergic depletion increases conditioned suppression to background stimuli in the rat
Autore:
Cassaday, HJ; Shilliam, CS; Marsden, CA;
Indirizzi:
Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England Univ NottinghamNottingham England NG7 2RD , Nottingham NG7 2RD, England Queens Med Ctr, Sch Med, Sch Biomed Sci, Nottingham NG7 2UH, England Queens Med Ctr Nottingham England NG7 2UH i, Nottingham NG7 2UH, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 83 - 92
SICI:
0269-8811(2001)15:2<83:SDICST>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATENT INHIBITION; 5,7-DIHYDROXYTRYPTAMINE LESIONS; TRYPTOPHAN-HYDROXYLASE; CONTEXTUAL CUES; FORNIX-FIMBRIA; 5-HYDROXYTRYPTAMINE; ASSOCIATIONS; DISCRETE; MDMA; CS;
Keywords:
classical conditioning; rat; serotonin depletion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Cassaday, HJ Univ Nottingham, Sch Psychol, Univ Pk, Nottingham NG7 2RD, England Univ Nottingham Univ Pk Nottingham England NG7 2RD , England
Citazione:
H.J. Cassaday et al., "Serotonergic depletion increases conditioned suppression to background stimuli in the rat", J PSYCHOPH, 15(2), 2001, pp. 83-92

Abstract

Dark Agouti rats were lesioned by intra-ventricular injection of 5,7-dihydroxytryptamine (DHT) and, 2 weeks later, learning was tested in a conditioned suppression of drinking procedure. Lesioned and vehicle-injected controlrats were conditioned with a discrete stimulus (tone or light conditioned stimulus, CS) twice paired with footshock (unconditioned stimulus), with orwithout a 30-s trace interval between these events to produce strong and weak learning conditions (a trace conditioning effect). During this conditioning session, the alternate stimulus (light or tone) was presented continuously in the background. Since the 5,7-DHT lesion also reduced the baseline licking response in the experimental chambers, we used drinking during the first minute, when this non-specific effect was minimal, as the dependent variable. We tested conditioning to target CS and to the alternative experimental background stimulus in exactly the same way in the same rats. We found that a level of serotonergic depletion without any intrinsic action on the trace conditioning effect nevertheless increased conditioning to the alternative background stimulus, irrespective of trace interval or stimulus modality. Thus, for both light and tone stimuli, the effect of serotonergic depletion depended only on the discrete target versus diffuse background roleof the stimulus in use. These findings have implications for the modification of human cognition by serotonergic drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:41:08