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Titolo:
Interactions between LY-354740, a Group II metabotropic agonist and the GABA(A)-benzodiazepine receptor complex in the rat elevated plus-maze
Autore:
Ferris, P; Seward, E; Dawson, GR;
Indirizzi:
Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Res Labs, Harlow CM20 2QR, Essex, England Merck Sharp & Dohme Ltd Harlow Essex England CM20 2QR 2QR, Essex, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 76 - 82
SICI:
0269-8811(2001)15:2<76:IBLAGI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL AMYGDALOID NUCLEUS; H-3 FLUNITRAZEPAM BINDING; GLUTAMATE RECEPTORS; NALOXONE BLOCKS; ENKEPHALIN LEVELS; BENZODIAZEPINES; ANTAGONISTS; DIAZEPAM; CHLORDIAZEPOXIDE; ANTICONVULSANT;
Keywords:
anxiety; benzodiazepine; elevated plus-maze; flumazenil; GABA(A) receptors; LY354740; naloxone; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Dawson, GR Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Res Labs, Terlings Pk,Eastwick Rd, Harlow CM20 2QR, Essex, England Merck Sharp & Dohme Ltd Terlings Pk,Eastwick Rd Harlow Essex England CM20 2QR
Citazione:
P. Ferris et al., "Interactions between LY-354740, a Group II metabotropic agonist and the GABA(A)-benzodiazepine receptor complex in the rat elevated plus-maze", J PSYCHOPH, 15(2), 2001, pp. 76-82

Abstract

Flumazenil, a benzodiazepine (BZ) receptor antagonist, and naloxone, a non-selective mu -receptor antagonist, were used to investigate whether the anxiolytic action of LY354740 [1S,2S,5R,6S-2aminobicyclo[3.1.0]hexane-2,6-dicarboxyl monohydrate], a Group II metabotropic glutamate receptor agonist, was mediated through the benzodiazepine binding site on the GABAA receptor and opioid pathways. LY354540 (1.0-10.0 mg/kg i.p.) induced dose-dependent anxiolytic-like effects in the rat elevated plus-maze. The anxiolytic-like effects of LY354740 (10.0 mg/kg) and the benzodiazepine receptor agonist, chlordiazepoxide (CDP, 5.0 mg/kg i.p.) were blocked by flumazenil (15.0 mg/kgi.p.). By contrast, naloxone (10.0 mg/kg i.p.) failed to: affect the anxiolytic-like effects of either LY354740 or CDP. The behaviour of animals treated with flumazenil or naloxone alone did not significantly differ from that of animals treated with vehicle alone. This study suggests that the anxiolytic-like effects of LY354740 on the elevated plus-maze may be directly orindirectly mediated by the benzodiazepine binding site on the GABA(A) receptor complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:14:17