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Titolo:
Different receptor subtypes are involved tn the serotonin-induced modulation of epileptiform activity in rat frontal cortex in vitro
Autore:
Bobula, B; Zahorodna, A; Bijak, M;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, Dept Physiol, Krakow, Poland Polish Acad Sci Krakow Poland t Pharmacol, Dept Physiol, Krakow, Poland
Titolo Testata:
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
fascicolo: 2, volume: 52, anno: 2001,
pagine: 265 - 274
SICI:
0867-5910(200106)52:2<265:DRSAIT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL ENTORHINAL CORTEX; HIPPOCAMPAL SLICE; 5-HT2A RECEPTORS; PARTIAL AGONISTS; IN-VITRO; NEURONS; INTERNEURONS; RESPONSES; CELLS; BRAIN;
Keywords:
5-HT; 5-HT1A receptors; 5-HT2 receptors; 5-HT1B receptors; 5-HT4 receptors cortical slice; synchronous activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Bijak, M Polish Acad Sci, Inst Pharmacol, Dept Physiol, Krakow, Poland Polish Acad Sci Krakow Poland ol, Dept Physiol, Krakow, Poland
Citazione:
B. Bobula et al., "Different receptor subtypes are involved tn the serotonin-induced modulation of epileptiform activity in rat frontal cortex in vitro", J PHYSL PH, 52(2), 2001, pp. 265-274

Abstract

The frontal cortex is innervated by serotonergic terminals from The raphe nuclei and it expresses diverse 5-HT receptor subtypes. We investigated theeffects of 5-HT and different 5-HT receptor subtype-selective agonists on spontaneous discharges which had developed in rat cortical slices perfused with a Mg2+-free medium and the GABA(A) receptor antagonist picrotoxin. Thefrequency of synchronous discharges, recorded extracellularly in superficial layers (II/III) of the frontal cortex, was dose-dependently enhanced by 5-HT (2.5-40 muM). That excitatory effect was blocked by the 5-HT2 receptorselective antagonist ketanserin. The 5-HT2A/2C receptor-selective agonist DOI and the 5-HT4 receptor agonist zacopride also increased the frequency of spontaneous discharges. In the presence of ketanserin, 5-HT decreased thedischarge rate; a similar effect was observed when the 5-HT1A receptor agonist 8-OH-DPAT or the 5-HT1B receptor agonist CGS-12066B was applied. The 5-HT3 receptor agonist m-CPBG was ineffective. In conclusion, 5-HT produces multiple effects on epileptiform activity in the frontal cortex via activation of various 5-HT receptor subtypes. The excitatory action of 5-HT, whichpredominates, is mediated mainly by 5-HT2 receptors. The inhibitory effects can be attributed to activation of 5-HT1A and 5-HT1B receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:15:43