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Titolo:
Mechanisms for the development of esophageal atresia
Autore:
Orford, J; Manglick, P; Cass, DT; Tam, PPL;
Indirizzi:
Royal Alexandra Hosp Children, Dept Surg Res, Westmead, NSW, Australia Royal Alexandra Hosp Children Westmead NSW Australia ead, NSW, Australia Univ Sydney, Dept Paediat & Child Hlth, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 d Hlth, Sydney, NSW 2006, Australia Childrens Med Res Inst, Embryol Unit, Westmead, NSW, Australia Childrens Med Res Inst Westmead NSW Australia , Westmead, NSW, Australia
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 7, volume: 36, anno: 2001,
pagine: 985 - 994
SICI:
0022-3468(200107)36:7<985:MFTDOE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RODENT EXPERIMENTAL-MODEL; DNA TOPOISOMERASE-II; TRACHEOESOPHAGEAL FISTULA; SONIC HEDGEHOG; RAT MODEL; VATER ASSOCIATION; PATCHED GENE; FETAL RATS; ADRIAMYCIN; APOPTOSIS;
Keywords:
esophageal atresia; tracheoesophageal fistula; notochord; Sonic hedgehog; apoptosis; VATER; Adriamycin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Orford, J Princess Margaret Hosp Children, Surg Serv Dept, Roberts Rd, Subiaco, WA 6008, Australia Princess Margaret Hosp Children Roberts Rd SubiacoWA Australia 6008
Citazione:
J. Orford et al., "Mechanisms for the development of esophageal atresia", J PED SURG, 36(7), 2001, pp. 985-994

Abstract

Background: There is no universally accepted theory to explain esophageal embryology and the abnormal development that produces esophageal atresia. Methods: The impact of Adriamycin administration on the pathogenesis of esophageal atresia was studied in the rat model of VATER association, from embryonic day (ED) 10 to ED 13. Results: Tissues in the ED10 Adriamycin-exposed embryos displayed less cell proliferation as shown by the reduced population of MIB-5-labelled cells. Cell apoptosis that is characteristic of the normal ED 12 lateral epithelial folds of the foregut (the prospective site of tracheoesophageal septation) was absent in the foregut of the Adriamycin-exposed embryo. Histologic examination of the ED 11-exposed embryo showed the presence of abnormal notochord that was stretched, split, or tethered to the foregut. This contrastswith the normal embryo in which the notochord was localized in close vicinity of the ventral part of the neural tube and separated from the foregut by ample amount of mesenchyme. The abnormal localization of the notochord was accompanied by the lack of down-regulation of the sonic hedgehog (Shh) activity in the prospective site of future tracheoesophageal separation in the exposed ED 12 embryo. Conclusion: The authors proposed that the ectopic location of the notochord leads to the disruption in Shh signalling that may underpin the development of esophageal atresia. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:30:22