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Titolo:
Oral Candida in HIV-infected heterosexuals and intravenous drug users in Thailand
Autore:
Nittayananta, W; Jealae, S; Winn, T;
Indirizzi:
Prince Songkla Univ, Fac Dent, Dept Stomatol, Songkhla 90112, Thailand Prince Songkla Univ Songkhla Thailand 90112 ol, Songkhla 90112, Thailand Prince Songkla Univ, Fac Med, Epidemiol Unit, Songkhla, Thailand Prince Songkla Univ Songkhla Thailand pidemiol Unit, Songkhla, Thailand Prince Songkla Univ, Fac Med, Microbiol Unit, Songkhla, Thailand Prince Songkla Univ Songkhla Thailand icrobiol Unit, Songkhla, Thailand
Titolo Testata:
JOURNAL OF ORAL PATHOLOGY & MEDICINE
fascicolo: 6, volume: 30, anno: 2001,
pagine: 347 - 354
SICI:
0904-2512(200107)30:6<347:OCIHHA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HOMOSEXUAL MEN; BISEXUAL MEN; ALBICANS; PREVALENCE; ANTIBODIES; LESIONS; SALIVA; AIDS;
Keywords:
AIDS; heterosexual; HIV; intravenous drug user; oral Candida; oral candidiasis; oral lesion; risk factor; Thailand;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nittayananta, W Prince Songkla Univ, Fac Dent, Dept Stomatol, Songkhla 90112, Thailand Prince Songkla Univ Songkhla Thailand 90112 12, Thailand
Citazione:
W. Nittayananta et al., "Oral Candida in HIV-infected heterosexuals and intravenous drug users in Thailand", J ORAL PATH, 30(6), 2001, pp. 347-354

Abstract

The objectives of this study were to determine levels of oral yeasts in Thai people at different stages of HIV infection compared with HIV-negative controls, to identify factors associated with the levels of oral Candida, and to determine whether the levels of the organism can be used as a predictive clinical marker in HIV-infected individuals. One hundred and eighty HIV-infected heterosexual persons and intravenous drug users (IVDUs) were enrolled (152 men, 28 women). Eighty-three HIV-free subjects from the same population were included as controls (48 men, 35 women). Oral yeasts were isolated in 103 HIV-infected subjects (57.2%) and 36 HIV-negative controls (43.3%). The mean number of colony forming units (CFU) of oral Candida in the first group was 1.9x10(4) CFU/ml (range 2.2x10(2)-4.0x10(6) CFU/ml), which wassignificantly different statistically when compared with 1.7x10(3) CFU/ml (range 4.0x10(2)-1.2x10(5) CFU/ml) in the control group (P=0.0000). The following factors are significantly associated statistical ly with the levels of oral Candida among the subjects (P<0.05): age, stage of HIV infection, total number of lymphocyte cell count, risk group, nutritional status, general health status, weight loss, type of oral lesions and number of oral lesions and number of sites affected. The study revealed that HIV serostatus, stage of HIV infection, and the occurrence of oral lesions among HIV-infected subjects may be predicted by the levels of oral Candida (P<0.05). By using a cut-off point of 2.0x10(3) CFU/ml, the sensitivity and predicitve values of the level of oral Candida on the HIV serostatus was higher than that based on the culture positivity results alone, although the specificity was similar. These findings suggest that, in conjunction with some other clinical signs and laboratory findings, the levels of oral Candida may be used asa predictive marker of disease in HIV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:14:24