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Titolo:
Defensin antimicrobial peptides in the oral cavity
Autore:
Dale, BA; Krisanaprakornkit, S;
Indirizzi:
Univ Washington, Dept Oral Biol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Oral Biol, Seattle, WA 98195 USA Univ Washington, Dept Periodont, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Periodont, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biochem, Seattle, WA 98195 USA Univ Washington, Dept Med Dermatol, Seattle, WA 98195 USA Univ WashingtonSeattle WA USA 98195 Med Dermatol, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF ORAL PATHOLOGY & MEDICINE
fascicolo: 6, volume: 30, anno: 2001,
pagine: 321 - 327
SICI:
0904-2512(200107)30:6<321:DAPITO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACHEAL EPITHELIAL-CELLS; NF-KAPPA-B; HUMAN NEUTROPHIL DEFENSINS; INNATE HOST-DEFENSE; BETA-DEFENSIN; HUMAN BETA-DEFENSIN-1; INDUCIBLE EXPRESSION; SALIVARY-GLANDS; WALL COMPONENTS; IMMUNE-SYSTEM;
Keywords:
epithelium; gingiva; host response; innate immunity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Dale, BA Univ Washington, Dept Oral Biol, Box 357132, Seattle, WA 98195 USA Univ Washington Box 357132 Seattle WA USA 98195 tle, WA 98195 USA
Citazione:
B.A. Dale e S. Krisanaprakornkit, "Defensin antimicrobial peptides in the oral cavity", J ORAL PATH, 30(6), 2001, pp. 321-327

Abstract

Epithelial surfaces are the most important route of entry of microbial pathogens. The interaction between bacteria and epithelial cells is now recognized to be a process in which the epithelial cells are active participants. This epithelial response is especially important in the oral cavity in which there is continual exposure to bacteria, fungi, and viruses. Humans havemany mechanisms that are responsible for keeping the balance between health and disease in this complex environment. These include the natural defenses of saliva and the host innate immune responses, as well as the ability to generate antibodies via acquired immune responses. This brief review willfocus on a recently recognized group of antimicrobial peptides, the defensins, and mainly on the beta -defensins that are expressed by epithelial cells. These peptides are part of the innate immune system; they have broad spectrum antibacterial and antifungal activity and they have properties that may serve to link innate immunity with the acquired immune system. Their role in oral health and susceptibility to disease is only now beginning to beappreciated, and many interesting questions remain to be explored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:49:48