Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cardiac neurotransmission imaging
Autore:
Carrio, I;
Indirizzi:
Hosp St Pau, Dept Nucl Med, Barcelona 08025, Spain Hosp St Pau BarcelonaSpain 08025 Dept Nucl Med, Barcelona 08025, Spain
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 7, volume: 42, anno: 2001,
pagine: 1062 - 1076
SICI:
0161-5505(200107)42:7<1062:CNI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC DILATED CARDIOMYOPATHY; MYOCARDIAL BETA-ADRENOCEPTORS; POSITRON-EMISSION-TOMOGRAPHY; I-123 METAIODOBENZYLGUANIDINE SCINTIGRAPHY; TRANSPLANTED HUMAN HEART; CORONARY-ARTERY DISEASE; SYMPATHETIC INNERVATION; IN-VIVO; HYPERTROPHIC CARDIOMYOPATHY; AUTONOMIC INNERVATION;
Keywords:
cardiac neurotransmission; cardiac PET; cardiac SPECT; cardiomyopathies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Carrio, I Hosp St Pau, Dept Nucl Med, Pare Claret 167, Barcelona 08025, Spain Hosp St Pau Pare Claret 167 Barcelona Spain 08025 08025, Spain
Citazione:
I. Carrio, "Cardiac neurotransmission imaging", J NUCL MED, 42(7), 2001, pp. 1062-1076

Abstract

Cardiac neurotransmission imaging with SPECT and PET allows in vivo assessment of presynaptic reuptake and neurotransmitter storage as well as of regional distribution and activity of postsynaptic receptors. In this way, thebiochemical processes that occur during neurotransmission can be investigated in vivo at a micromolar level using radiolabeled neurotransmitters and receptor ligands. SPECT and PET of cardiac neurotransmission characterize myocardial neuronal function in primary cardio-neuropathies, in which the heart has no significant structural abnormality, and in secondary cardioneuropathies caused by the metabolic and functional changes that take place in different diseases of the heart. In patients with heart failure, the assessment of sympathetic activity has important prognostic implications and will result in better therapy and outcome. In diabetic patients, scintigraphic techniques allow the detection of autonomic neuropathy in early stages of the disease. In conditions with:a risk of sudden death, such as idiopathic ventricular tachycardia and arrhythmogenic right ventricular cardiomyopathy, PET and SPECT reveal altered neuronal function when no other structural abnormality is seen. In patients with ischemic heart disease, heart transplantation, drug-induced cardiotoxicity, and dysautonomias, assessment of neuronal function can help characterize the disease and improve prognostic stratification, Future directions include the development of tracers for new types of receptors, the targeting of second messenger molecules, and the early assessment of cardiac neurotransmission in genetically predisposed subjectsfor prevention and early treatment of heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:34:55