Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis
Autore:
Allen, JW; Eldadah, BA; Huang, XL; Knoblach, SM; Faden, AI;
Indirizzi:
Georgetown Univ, Dept Neurosci, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 eurosci, Washington, DC 20007 USA Georgetown Univ, Inst Cognit & Computat Sci, Washington, DC USA GeorgetownUniv Washington DC USA nit & Computat Sci, Washington, DC USA Georgetown Univ, Interdisciplinary Program Neurosci, Washington, DC USA Georgetown Univ Washington DC USA y Program Neurosci, Washington, DC USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 1, volume: 65, anno: 2001,
pagine: 45 - 53
SICI:
0360-4012(20010701)65:1<45:MCAIIB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; CEREBELLAR GRANULE CELLS; ALZHEIMERS-DISEASE; HIPPOCAMPAL-NEURONS; CORTICAL-NEURONS; DEATH; ACTIVATION; INJURY; BRAIN; PROTEASES;
Keywords:
caspase inhibitors; cerebellar granule cells; cortical neurons; in vitro;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Faden, AI Georgetown Univ, Dept Neurosci, EP-12 Res Bldg,3970 Reservoir RdNW, Washington, DC 20007 USA Georgetown Univ EP-12 Res Bldg,3970 ReservoirRd NW Washington DC USA 20007
Citazione:
J.W. Allen et al., "Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis", J NEUROSC R, 65(1), 2001, pp. 45-53

Abstract

beta -amyloid peptide (A beta) has been implicated in the pathogenesis of Alzheimer disease and has been reported to induce apoptotic death in cell culture. Cysteine proteases, a family of enzymes known as caspases, mediate cell death in many models of apoptosis. Multiple caspases have been implicated in A beta toxicity; these reports are conflicting. We show that treatment of cerebellar granule cells (CGC) with A beta (25-35) causes apoptosis associated with increased activity of caspases-2, -3 and -6. Selective inhibition of each of these three caspases provides significant protection against A beta -mediated apoptosis, In contrast, no change in caspase-1 activitywas seen after A beta (25-35) application, nor was inhibition of caspase-1neuroprotective. Similar to CGC, cortical neuronal cultures treated with Abeta (25-35) demonstrate increased caspase-3 activity but not caspase-1 activity. Furthermore, significant neuroprotection is elicited by selective inhibition of caspase-3 in cortical neurons administered A beta (25-35) whereas selective caspase-1 inhibition has no effect. Taken together, these findings indicate that multiple executioner caspases may be involved in neuronal apoptosis induced by A beta. J. Neurosci. Res. 65:45-53, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:00:22