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Titolo:
Functional striatal hypodopaminergic activity in mice lacking adenosine A(2A) receptors
Autore:
Dassesse, D; Massie, A; Ferrari, R; Ledent, C; Parmentier, M; Arckens, L; Zoli, M; Schiffmann, SN;
Indirizzi:
Free Univ Brussels, Dept Neurosci, Neurophysiol Lab, European Grad Sch Neurosci, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 sci, B-1070 Brussels, Belgium Katholieke Univ Leuven, European Grad Sch Neurosci, Lab Neuroendocrinol & Immunol Biotechnol, Louvain, Belgium Katholieke Univ Leuven Louvain Belgium nol Biotechnol, Louvain, Belgium Free Univ Brussels, Sch Med, IRIBHN, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 BHN, B-1070 Brussels, Belgium Univ Modena & Reggio Emilia, Dipartimento Sci Biomed, Sez Fisiol, Modena, Italy Univ Modena & Reggio Emilia Modena Italy med, Sez Fisiol, Modena, Italy
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 1, volume: 78, anno: 2001,
pagine: 183 - 198
SICI:
0022-3042(200107)78:1<183:FSHAIM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR GLUTAMATE LEVELS; REGULATED GENE-EXPRESSION; CEREBELLAR GRANULE CELLS; MESSENGER-RNA EXPRESSION; TIME-DEPENDENT CHANGES; IMMEDIATE-EARLY GENES; C-FOS EXPRESSION; RAT STRIATUM; IN-VIVO; ACID DECARBOXYLASE;
Keywords:
adenosine; A(24) receptor; dopamine release; glutamic acid decarboxylase; immediate early gene; neuropeptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Dassesse, D Free Univ Brussels, Dept Neurosci, Neurophysiol Lab, European Grad Sch Neurosci, Campus Erasme,CP 601,808 Route Lennik, B-1070 Brussels, Belgium Free Univ Brussels Campus Erasme,CP 601,808 Route Lennik Brussels Belgium B-1070
Citazione:
D. Dassesse et al., "Functional striatal hypodopaminergic activity in mice lacking adenosine A(2A) receptors", J NEUROCHEM, 78(1), 2001, pp. 183-198

Abstract

Adenosine and caffeine modulate locomotor activity and striatal gene expression, partially through the activation and blockade of striatal A(2A) receptors, respectively. The elucidation of the roles of these receptors benefits from the construction of A(2A) receptor-deficient mice (A(2A)-R-/-). These mice presented alterations in locomotor behaviour and striatal expression of genes studied so far, which are unexpected regarding the specific expression of A(2A) receptor by striatopallidal neurones. To clarify the functions of A(2A) receptors in the striatum and to identify the mechanisms leading to these unexpected modifications, we studied the basal expression of immediate early and constitutive genes as well as dopamine and glutamate neurotransmission in the striatum. Basal zif268 and arc mRNAs expression was reduced in mutant mice by 60-80%, not only in the striatum but also widespread in the cerebral cortex and hippocampus, Striatal expression of substance P and enkephalin mRNAs was reduced by about 50% and 30%, respectively, whereas the expression of GAD67 and GAD65 mRNAs was slightly increased and unaltered, respectively. In vivo microdialysis in the striatum revealed a 45% decrease in the extracellular dopamine concentration and three-fold increasein extracellular glutamate concentration. This was associated with an up-regulation of D-1 and D-2 dopamine receptors expression but not with changesin ionotropic glutamate receptors, The levels of tyrosine hydroxylase and of striatal and cortical glial glutamate transporters as well as adenosine A(1) receptors expression were indistinguishable between A(2A)-R-/- and wild-type mice. Altogether these results pointed out that the lack of A(2A) receptors leads to a functional hypodopaminergic state and demonstrated that A(2A) receptors are necessary to maintain a basal level in immediate early and constitutive genes expression in the striatum and cerebral cortex, possibly via their control of dopamine pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:56:05