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Titolo:
Matrix-assisted laser desorption/ionization, fast atom bombardment and plasma desorption mass spectrometry of polyethylene glycol esters of (2-benzothiazolon-3-yl) acetic acid
Autore:
Mincheva, Z; Hadjieva, P; Kalcheva, V; Seraglia, R; Traldi, P; Przybylski, M;
Indirizzi:
Univ Sofia, Dept Chem, Sofia 1164, Bulgaria Univ Sofia Sofia Bulgaria 1164 iv Sofia, Dept Chem, Sofia 1164, Bulgaria CNR, Area Ric Padova, I-35100 Padua, Italy CNR Padua Italy I-35100CNR, Area Ric Padova, I-35100 Padua, Italy CNR, Ctr Studio Stabil & Reattivita Composti Coordinaz, I-35100 Padua, Italy CNR Padua Italy I-35100 ttivita Composti Coordinaz, I-35100 Padua, Italy Univ Konstanz, Fak Chem, D-78457 Constance, Germany Univ Konstanz Constance Germany D-78457 Chem, D-78457 Constance, Germany
Titolo Testata:
JOURNAL OF MASS SPECTROMETRY
fascicolo: 6, volume: 36, anno: 2001,
pagine: 626 - 632
SICI:
1076-5174(200106)36:6<626:MLDFAB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLY(ETHYLENE GLYCOLS); SYNTHETIC-POLYMERS; ION CHROMATOGRAPHY; IONIZATION-TIME; GAS-PHASE;
Keywords:
2-benzothiazolon-3-yl)acetyl terminal groups; polyethylene glycol esters; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; fast atom bombardment mass spectrometry; plasma desorption mass spectrometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Mincheva, Z Univ Sofia, Dept Chem, 1 james Bourchier Ave, Sofia 1164, Bulgaria Univ Sofia 1 james Bourchier Ave Sofia Bulgaria 1164 Bulgaria
Citazione:
Z. Mincheva et al., "Matrix-assisted laser desorption/ionization, fast atom bombardment and plasma desorption mass spectrometry of polyethylene glycol esters of (2-benzothiazolon-3-yl) acetic acid", J MASS SPEC, 36(6), 2001, pp. 626-632

Abstract

Fast atom bombardment (FAB), matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) and plasma desorption (PD) mass spectra of newly synthesized polyethylene glycols (PEGs), (M-w 600-4000 Da) chemically modified with biologically active (2-benzothiazolon-3-yl)acetyl end-groups are described (products 1-6). The spectra were also used for the determination of the molecular mass characteristics (number average (M,) and weight average (M,) molecular masses) of the initial and modified PEGs. As expected, M, and M, of the modified samples are higher than those of the nonmodified samples. However, it is shown that molecular mass dispersity (determined by the comparison of the polydispersity indices (PDI = M-w/M-n) of both types ofPEGs) essentially do not change during this modification. The FAB mass spectra, together with molecular species, show the presence of abundant [M + Na](+) ions of product 1 and [M + Na + H](+) species of 2 and 3, and [M + Na+ 2H](+) of product 4. Two main series of fragment ions, derived from the cleavage of the ether bonds, are observed. The number fractions of the molecular adduct ions and fragment adduct ions, determined from the FAB and PD mass spectra of the modified PEGs, are compared. The MALDI-TOF mass spectraof compounds 1-6 show the presence of two series of polymers. The most abundant peaks are due to [M + Na](+) and [M + K](+) ions originating from thepolymers, in which the two terminal hydroxyl groups of PEGs are esterifiedwith (2-benzothiazolon-3-yl)acetic acid. The less abundant peaks are due to the monosubstituted polymers. Copyright (C) 2001 John Wiley & Sons, Ltd.

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Documento generato il 19/09/20 alle ore 17:55:42