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Titolo:
Perspectives on the use of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for short tandem repeat genotyping in the post-genome era
Autore:
Null, AP; Muddiman, DC;
Indirizzi:
Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA Virginia Commonwealth Univ Richmond VA USA 23284 , Richmond, VA 23284 USA
Titolo Testata:
JOURNAL OF MASS SPECTROMETRY
fascicolo: 6, volume: 36, anno: 2001,
pagine: 589 - 606
SICI:
1076-5174(200106)36:6<589:POTUOE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASSISTED-LASER-DESORPTION/IONIZATION; POLYMERASE-CHAIN-REACTION; INFRARED MULTIPHOTON DISSOCIATION; MULTIPLY-CHARGED OLIGONUCLEOTIDES; CAPILLARY-ELECTROPHORESIS; NONCOVALENT COMPLEXES; SPACE-CHARGE; FT-ICR; DNA POLYMORPHISMS; REACTION PRODUCTS;
Keywords:
electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry; short tandem repeats; genotyping; DNA; human genome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
137
Recensione:
Indirizzi per estratti:
Indirizzo: Muddiman, DC Virginia Commonwealth Univ, Dept Chem, 1001 W Main St, Richmond, VA 23284 USA Virginia Commonwealth Univ 1001 W Main St Richmond VA USA 23284
Citazione:
A.P. Null e D.C. Muddiman, "Perspectives on the use of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for short tandem repeat genotyping in the post-genome era", J MASS SPEC, 36(6), 2001, pp. 589-606

Abstract

The recent completion of the first rough draft of the human genome has provided fundamental information regarding our genetic make-up; however, the post-genome era will certainly require a host of new technologies to addresscomplex biological questions. In particular, a rapid and accurate approachto characterize genetic markers, including short tandem repeats (STRs) andsingle nucleotide polymorphisms (SNPs) is demanded. STRs are the most informative of the two polymorphisms owing to their remarkable variability and even dispersity throughout eukaryotic genomes. Mass spectrometry is rapidlybecoming significant method in DNA analysis and has high probability of revolutionizing the way in which scientists probe the human genome. It is ourresponsibility as biomolecular mass spectrometrists to understand the issues in genetic analysis and the capabilities of mass spectrometry so that wemay fulfill our role in developing a rapid, reliable technology to answer specific biological questions. This perspective is intended to familiarize the mass spectrometry community with modem genomics and to report on the current state of mass spectrometry, specifically electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry, for characterization of STRs. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:31:34