Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased levels of tPA antigen and tPA/PAI-1 complex in myotonic dystrophy
Autore:
Johansson, A; Boman, K; Cederquist, K; Forsberg, H; Olsson, T;
Indirizzi:
Univ Umea Hosp, Dept Publ Hlth & Clin Med, SE-90185 Umea, Sweden Univ UmeaHosp Umea Sweden SE-90185 th & Clin Med, SE-90185 Umea, Sweden Univ Umea Hosp, Dept Med Biosci, SE-90185 Umea, Sweden Univ Umea Hosp Umea Sweden SE-90185 pt Med Biosci, SE-90185 Umea, Sweden Skelleftea Cty Hosp, Dept Med, Skelleftea, Sweden Skelleftea Cty Hosp Skelleftea Sweden osp, Dept Med, Skelleftea, Sweden Boden Hosp, Dept Internal Med, Boden, Sweden Boden Hosp Boden SwedenBoden Hosp, Dept Internal Med, Boden, Sweden
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 6, volume: 249, anno: 2001,
pagine: 503 - 510
SICI:
0954-6820(200106)249:6<503:ILOTAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; HUMAN ADIPOSE-TISSUE; FIBRINOLYTIC-ACTIVITY; INSULIN-RESISTANCE; LIPOPROTEIN-LIPASE; DIABETES-MELLITUS; HEART-DISEASE; CELLS; HYPERTRIGLYCERIDEMIA; EXPANSION;
Keywords:
body composition; dystrophia myotonica; fibrinolysis; lipids; myotonic dystrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Olsson, T Univ Umea Hosp, Dept Publ Hlth & Clin Med, SE-90185 Umea, SwedenUniv Umea Hosp Umea Sweden SE-90185 Med, SE-90185 Umea, Sweden
Citazione:
A. Johansson et al., "Increased levels of tPA antigen and tPA/PAI-1 complex in myotonic dystrophy", J INTERN M, 249(6), 2001, pp. 503-510

Abstract

Objective. To assess the fibrinolytic system in myotonic dystrophy (DM1), a disease connected to features of the metabolic syndrome, including a prominent insulin resistance, increased body fat mass, and hypertriglyceridaemia. We hypothesized that abnormalities in the fibrinolytic system are linkedto metabolic dysfunction in DM1. Design. Circulating morning levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor type 1 (PAI-1) antigens, tPA/PAI-1 complex, lipids and insulin were determined. Genetic analyses, including calculation of allele size, were performed in all patients. Body fat mass was estimated with bioelectrical impedance analysis. Setting. Out-patient clinic in collaboration with Umea University Hospital. Subjects. A total of 42 otherwise healthy patients with DM1 (22 men, 20 women; median age 41.5 years) and 50 controls (27 men, 23 women; median age 42.0 years),Main outcome measures. The tPA and PAI-1 antigens, tPA/PAI-1 complex, blood lipids and body fat mass. Results. The tPA antigen and tPA/PAI-1 complex levels were significantly increased in DM1 patients (P < 0.001 and P < 0.05, respectively) whilst levels of PAI-1 did not differ from controls. Triglyceride levels were increased (P < 0.001) whereas HDL cholesterol levels were lower in DM1 patients (P < 0.05). Body fat mass was increased in DM1 patients (P < 0.001). Conclusions. The fibrinolytic system is disturbed in DM1 patients; with increased levels of tPA and tPA/PAI-1 complex but paradoxically unaltered levels of PAI-1, in spite of a severely increased body fat mass. This may imply an abnormal function of adipose tissue in DM1, and calls for further studies of the fibrinolytic system in this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:33:39